European Heart Journal Advance Access originally published online on September 25, 2006
European Heart Journal 2006 27(21):2588-2605; doi:10.1093/eurheartj/ehl254
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Expert consensus document on arterial stiffness: methodological issues and clinical applications
1 Department of Pharmacology and Hôpital Européen Georges Pompidou, Université Paris-Descartes, Faculté de Médecine, Assistance Publique—Hôpitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
2 Cardiology Department, University of Wales, Cardiff, UK
3 University of Ghent, Heymans Institute of Pharmacology, Ghent, Belgium
4 Department of Internal Medicine, Milano-Bicocca University, Monza, Italy
5 Service of Angiology, CHUV, University of Lausanne, Switzerland
6 Department of Nephrology, Manhes Hospital, Fleury-Merogis, France
7 Cardiovascular and Sexual Health Unit, Hippokration Hospital, Athens
8 Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge, UK
9 Department of Medicine, Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
Received 6 May 2006; revised 22 August 2006; accepted 31 August 2006; online publish-ahead-of-print 25 September 2006.
* Corresponding author. Tel: +44 33 1 56 09 39 91; fax: +44 33 1 56 09 39 92. E-mail address: stephane.laurent{at}egp.ap-hop-paris.fr
See page 2497 for the editorial comment on this article (doi:10.1093/eurheartj/ehl312)
In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.
Key Words: Artery • Arterial stiffness • Haemodynamics • Pathophysiology • Prognosis • Cardiovascular events
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