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European Heart Journal Advance Access originally published online on September 25, 2006
European Heart Journal 2006 27(21):2588-2605; doi:10.1093/eurheartj/ehl254
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Expert consensus document on arterial stiffness: methodological issues and clinical applications

Stephane Laurent1,*, John Cockcroft2, Luc Van Bortel3, Pierre Boutouyrie1, Cristina Giannattasio4, Daniel Hayoz5, Bruno Pannier6, Charalambos Vlachopoulos7, Ian Wilkinson8, Harry Struijker-Boudier9 on behalf of the European Network for Non-invasive Investigation of Large Arteries

1 Department of Pharmacology and Hôpital Européen Georges Pompidou, Université Paris-Descartes, Faculté de Médecine, Assistance Publique—Hôpitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
2 Cardiology Department, University of Wales, Cardiff, UK
3 University of Ghent, Heymans Institute of Pharmacology, Ghent, Belgium
4 Department of Internal Medicine, Milano-Bicocca University, Monza, Italy
5 Service of Angiology, CHUV, University of Lausanne, Switzerland
6 Department of Nephrology, Manhes Hospital, Fleury-Merogis, France
7 Cardiovascular and Sexual Health Unit, Hippokration Hospital, Athens
8 Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge, UK
9 Department of Medicine, Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands

Received 6 May 2006; revised 22 August 2006; accepted 31 August 2006; online publish-ahead-of-print 25 September 2006.

* Corresponding author. Tel: +44 33 1 56 09 39 91; fax: +44 33 1 56 09 39 92. E-mail address: stephane.laurent{at}egp.ap-hop-paris.fr

See page 2497 for the editorial comment on this article (doi:10.1093/eurheartj/ehl312)

In recent years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is increasingly used in the clinical assessment of patients. Although several papers have previously addressed the methodological issues concerning the various indices of arterial stiffness currently available, and their clinical applications, clinicians and researchers still report difficulties in selecting the most appropriate methodology for their specific use. This paper summarizes the proceedings of several meetings of the European Network for Non-invasive Investigation of Large Arteries and is aimed at providing an updated and practical overview of the most relevant methodological aspects and clinical applications in this area.

Key Words: Artery • Arterial stiffness • Haemodynamics • Pathophysiology • Prognosis • Cardiovascular events


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HypertensionHome page
E. Agabiti-Rosei, G. Mancia, M. F. O'Rourke, M. J. Roman, M. E. Safar, H. Smulyan, J.-G. Wang, I. B. Wilkinson, B. Williams, and C. Vlachopoulos
Central Blood Pressure Measurements and Antihypertensive Therapy: A Consensus Document
Hypertension, July 1, 2007; 50(1): 154 - 160.
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Am. J. Respir. Crit. Care Med.Home page
C. Vogelmeier and R. Bals
Chronic Obstructive Pulmonary Disease and Premature Aging
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1217 - 1218.
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Am. J. Respir. Crit. Care Med.Home page
R. Sabit, C. E. Bolton, P. H. Edwards, R. J. Pettit, W. D. Evans, C. M. McEniery, I. B. Wilkinson, J. R. Cockcroft, and D. J. Shale
Arterial Stiffness and Osteoporosis in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1259 - 1265.
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Eur Heart JHome page
Authors/Task Force Members:, G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A. M. Heagerty, S. E. Kjeldsen, et al.
2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
Eur. Heart J., June 11, 2007; (2007) ehm236v1.
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J. Am. Soc. Nephrol.Home page
M. M.H. Hermans, R. Henry, J. M. Dekker, J. P. Kooman, P. J. Kostense, G. Nijpels, R. J. Heine, and C. D.A. Stehouwer
Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1942 - 1952.
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HypertensionHome page
S. Laurent and P. Boutouyrie
Recent Advances in Arterial Stiffness and Wave Reflection in Human Hypertension
Hypertension, June 1, 2007; 49(6): 1202 - 1206.
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HypertensionHome page
N. A. Jatoi, P. Jerrard-Dunne, J. Feely, and A. Mahmud
Impact of Smoking and Smoking Cessation on Arterial Stiffness and Aortic Wave Reflection in Hypertension
Hypertension, May 1, 2007; 49(5): 981 - 985.
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J Am Coll CardiolHome page
I. J. Kullo and A. R. Malik
Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification
J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426.
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Eur Heart JHome page
M. F. O'Rourke and S. S. Franklin
Arterial stiffness: reflections on the arterial pulse
Eur. Heart J., November 1, 2006; 27(21): 2497 - 2498.
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