European Heart Journal Advance Access originally published online on January 9, 2006
European Heart Journal 2006 27(6):722-728; doi:10.1093/eurheartj/ehi717
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Association between the metabolic syndrome and parental history of premature cardiovascular disease
1INSERM U508, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
2Faculté de Médecine, Université Lille II, Lille, France
3INSERM U558, Faculté de Médecine Purpan, Toulouse, France
4Laboratoire d'Epidémiologie et de Santé Publique, Strasbourg, France
5INSERM U258, Hôpital Paul Brousse, Villejuif, France
Received 13 May 2005; revised 13 October 2005; accepted 15 December 2005; online publish-ahead-of-print 9 January 2006.
* Corresponding author. Tel: +33 3 2087 7373; fax: +33 3 2087 7894. E-mail address: jean.dallongeville{at}pasteur-lille.fr
Aims The goal of this study is to assess the association between the metabolic syndrome (MS) and parental history of cardiovascular disease (CVD).
Methods and results Participants were recruited in a population survey of 3441 men and women, aged 35–64. MS was defined with NCEP-III guidelines. Familial history of myocardial infarction (MI), angina, and stroke was assessed with a standardized questionnaire. Parental premature CVD was defined if CVD occurred before 55/65 years in the father/mother. A total of 390 men and 281 women had MS. Positive parental CVD was associated with MS in women (43.0 vs. 36.8%, P<0.001) but not in men (36.9 vs. 31.8%, P=0.06). Similarly, parental premature CVD was associated with MS in women (19.2 vs. 11.8%, P<0.0007) but not in men (11.1 vs. 11.1%, ns). In women with MS, the age, centre, and educational level adjusted odds ratios [OR (95% CI)] of having a positive parental premature stroke was 1.84 (1.0–3.38), P=0.049. This OR was 1.76 (1.23–2.76), P=0.007 for combined parental premature MI and stroke and 1.67 (1.17–2.38), P=0.004 for combined premature MI, stroke, and angina. After further adjustment on personal coronary heart disease and CVD risk factors, the ORs of having a positive parental history of combined premature MI and stroke [1.75 (1.11–2.76), P=0.016] or MI, stroke, and angina [1.79 (1.21–2.63), P=0.003], remained statistically significant, in women with MS.
Conclusion The MS is associated with parental premature CVD independently of classical CV risk factors, suggesting that MS is a contributor to the familial aggregation of premature CVD.
Key Words: Metabolic syndrome • Familial coronary heart disease • Myocardial infarction • Stroke
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