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European Heart Journal Advance Access originally published online on January 18, 2006
European Heart Journal 2006 27(7):802-807; doi:10.1093/eurheartj/ehi730
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Prognostic significance of plasma osteopontin levels in patients with chronic stable angina

Piercarlo Minoretti1,2, Colomba Falcone2,3, Margherita Calcagnino3, Enzo Emanuele2, Maria P. Buzzi3, Enrico Coen2 and Diego Geroldi2,*

1Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Lecco, Italy
2Interdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, Viale Taramelli 24, I-27100 Pavia, Italy
3Department of Cardiology, IRCCS San Matteo Hospital, University of Pavia, Pavia, Italy

Received 20 September 2005; revised 16 December 2005; accepted 23 December 2005; online publish-ahead-of-print 18 January 2006.

* Corresponding author. Tel: +39 0382 528 341; fax: +39 0382 526 259. E-mail address: ccirmc{at}unipv.it

See page 766 for the editorial comment on this article (doi:10.1093/eurheartj/ehi743)

Aims Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD). The present study assessed the relationship between plasma OPN concentrations and prognosis in patients with chronic stable angina (CSA).

Methods and results OPN was measured in baseline plasma samples from 799 patients with stable angina pectoris and angiographically documented CAD. Participants were prospectively followed-up for a median of 2.7 years (maximum 4.1 years). The primary study endpoint was the composite of non-fatal myocardial infarction and death from cardiovascular causes. In the univariate Cox proportional hazard analysis, the log-transformed OPN level [hazard ratio (HR) 1.79, 95% CI 1.35–2.36, P<0.001] was significantly related to adverse outcome. In addition, hypertension, levels of C-reactive protein, and statin use were associated with future adverse events. Levels of OPN (HR, 1.88; P<0.001) and C-reactive protein (HR, 1.42; P=0.003), as well as the presence of hypertension (HR, 2.39; P=0.008) remained statistically significant, independent predictors of adverse cardiovascular outcome in a multivariable Cox proportional hazard analysis.

Conclusion Baseline levels of OPN are an independent predictor of future adverse cardiac events in patients with CSA and may be useful for risk stratification.

Key Words: Osteopontin • Stable angina • Prognosis • Risk stratification


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