European Heart Journal Advance Access originally published online on February 13, 2006
European Heart Journal 2006 27(9):1038-1047; doi:10.1093/eurheartj/ehi754
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Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin
1 Department of Medicine and Cardiology, Århus University Hospital, Århus, Denmark
2 AstraZeneca R&D, Molndal, Sweden
3 Cardiovascular Medicine Department, University of Nottingham, Nottingham, UK
4 Department of Hematology, Ullevaal University Hospital, Oslo, Norway
5 AstraZeneca Research and Development, Charnwood, UK
6 AstraZeneca Research and Development, Wilmington, DE, USA
Received 19 July 2005; revised 4 January 2006; accepted 13 January 2006; online publish-ahead-of-print 13 February 2006.
* Corresponding author. Tel: +45 89 497 613; fax: +45 89 497 619. E-mail address: steen.husted{at}as.aaa.dk
See page 1010 for the editorial comment on this article (doi:10.1093/eurheartj/ehi851)
Aims This double-blind, parallel-group study was conducted to assess the pharmacodynamics, pharmacokinetics, and safety of AZD6140, the first oral, reversible adenosine diphosphate (ADP) receptor antagonist.
Methods and results Patients (n=200) with atherosclerosis were randomized to receive AZD6140 50, 100, or 200 mg twice daily (bid) or 400 mg daily (qd) or clopidogrel 75 mg qd for 28 days. All groups received aspirin 75–100 mg qd. AZD6140 (100 and 200 mg bid, 400 mg qd) rapidly and nearly completely inhibited ADP-induced platelet aggregation after initial dosing (day 1) and at day 28. On day 1, peak final-extent inhibition of platelet aggregation (IPA) was observed 2–4 h post-dose with AZD6140, whereas clopidogrel minimally inhibited platelet aggregation (mean percentage IPA<20%, all time points). Four hour post-dose at steady state, the three higher doses of AZD6140 produced comparable final-extent mean percentage IPA (
90–95%), which exceeded that with AZD6140 50 mg bid or clopidogrel (60%). AZD6140 was generally well tolerated. All bleeding events, except one in a patient receiving 400 mg qd, were minor and of mild-to-moderate severity.
Conclusion AZD6140 100 and 200 mg bid were well tolerated and were superior to AZD6140 50 mg bid and clopidogrel 75 mg qd with regard to antiplatelet efficacy.
Key Words: Platelets • Drugs • Atherosclerosis
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