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European Heart Journal Advance Access originally published online on May 5, 2007
European Heart Journal 2007 28(11):1283-1288; doi:10.1093/eurheartj/ehm112
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Intravascular ultrasound radiofrequency analysis of coronary atherosclerosis: an emerging technology for the assessment of vulnerable plaque

Sameer K. Mehta, Justin R. McCrary, Andrew D. Frutkin, William J.S. Dolla and Steven P. Marso*

Mid America Heart Institute, University of Missouri-Kansas City, Saint Luke's Hospital, 4401 Wornall Road, Kansas City, MI 64111, USA

Received 14 September 2006; revised 6 February 2007; accepted 22 March 2007; online publish-ahead-of-print 5 May 2007.

* Corresponding author. Tel: +1 816 932 5773; fax: +1 816 932 5798. E-mail address: smarso{at}saint-lukes.org

Evaluation of atherosclerotic plaque composition and morphometry may yield insight into plaque biology and the mechanisms of plaque-associated thrombosis. Analysis of intravascular ultrasound radiofrequency (IVUS-RF) backscatter signal is one technology that provides in vivo assessment of both atherosclerotic plaque composition and morphometry. We summarize three different approaches to IVUS-RF and critique the studies using this technology. In addition, we address the potential application of IVUS-RF to assess vulnerable plaque.

Key Words: Intravascular ultrasound • Radiofrequency backscatter • Coronary artery disease • Vulnerable plaque


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