European Heart Journal Advance Access originally published online on May 31, 2007
European Heart Journal 2007 28(14):1759-1764; doi:10.1093/eurheartj/ehm175
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Intravascular ultrasound assessment of remodelling and reference segment plaque burden in type-2 diabetic patients
1 Catheterization Laboratory, Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark
2 Cardiovascular Research Foundation, New York, NY, USA
3 Department of Cardiology, Aarhus University Hospital, Skejby Hospital, Aarhus, Denmark
4 Department of Cardiology, Gentofte Hospital, Gentofte, Denmark
Received 10 October 2006; revised 29 March 2007; accepted 18 April 2007; online publish-ahead-of-print 31 May 2007.
* Corresponding author. Tel: +45 6541 2691; fax: +45 6312 1730. E-mail address: okkels{at}dadlnet.dk
Aims: Intravascular ultrasound (IVUS) assesses arterial remodelling by comparing the lesion external elastic membrane (EEM) with the reference segments; however, reference segments are rarely disease-free. The aim was to assess lesion and reference segment remodelling and plaque burden in patients with type-2 diabetes mellitus.
Methods and results: We used pre-intervention IVUS to study 62 de novo lesions in 43 patients with type-2 diabetes mellitus. The lesion site was the image slice with the smallest lumen cross-sectional area (CSA). The proximal and distal reference segments were the most normal-looking segments within 5 mm proximal and distal to the lesion. Plaque burden was measured as plaque CSA/EEM CSA. The remodelling index was defined as lesion EEM CSA/mean reference EEM CSA. Reference segment plaque burden measured 0.54 ± 0.09. The majority of lesions (83.9%) had negative remodelling (lesion EEM < reference). Similarly, the slope of the regression line relating EEM to plaque CSA within the lesion was less than the reference substantiating negative remodelling. The reference segment plaque burden correlated inversely with the difference between IVUS lumen and quantitative coronary angiographic artery size [slope = –0.12 (95% CI –0.17 to –0.07); P < 0.001] in all patients with type-2 diabetes mellitus.
Conclusion: Lesions in type-2 diabetic patients are different from previous reports in non-diabetics. Lesions in type-2 diabetics are characterized by a large reference segment plaque burden and negative lesion site remodelling. These IVUS findings may explain the angiographic appearance of small arteries in diabetic patients.
Key Words: Remodelling • Diabetes • Intravascular ultrasound • Reference vessel
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