European Heart Journal Advance Access originally published online on October 11, 2007
European Heart Journal 2007 28(21):2667-2677; doi:10.1093/eurheartj/ehm426
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Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction
1 Department of Medicine, Section of Cardiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
2 Department of Molecular Pathology, MD Anderson Cancer Center, University of Texas, SCRB2, Box 951, 7435 Fannin Street, Houston, TX 77054, USA
3 Department of Radiology, Section of Nuclear Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Received 12 February 2007; revised 1 August 2007; accepted 31 August 2007; online publish-ahead-of-print 11 October 2007.
* Corresponding author. Tel: +1 713 834 6102; fax: +1 713 834 6103. E-mail address: ealtmd{at}aol.com
See page 2565 for the editorial comment on this article (doi:10.1093/eurheartj/ehm435)
Aims: This study was designed to assess whether intracoronary application of adipose tissue-derived stem cells (ADSCs) compared with bone marrow-derived stem cells (BMSCs) and control could improve cardiac function after 30 days in a porcine acute myocardial infarction/reperfusion model.
Methods and results: An acute transmural porcine myocardial infarction was induced by inflating an angioplasty balloon for 180 min in the mid-left anterior descending artery. Two million cultured autologous stem cells were intracoronary injected through the central lumen of the inflated balloon catheter. Analysis of scintigraphic data obtained after 28 ± 3 days showed that both absolute and relative perfusion defect decreased significantly after intracoronary administration of ADSCs or BMSCs (relative 30 or 31%, respectively), compared with carrier administration alone (12%, P = 0.048). Left ventricular ejection fraction after 4 weeks increased significantly more after ADSC and BMSC administration than after carrier administration: 11.39 ± 4.62 and 9.59 ± 7.95%, respectively vs. 1.95 ± 4.7%, P = 0.02). The relative thickness of the ventricular wall in the infarction area after cell administration was significantly greater than that after carrier administration. The vascular density of the border zone also improved. The grafted cells co-localized with von Willebrand factor and alpha-smooth muscle actin and incorporated into newly formed vessels.
Conclusion: This is the first study to show that not only bone marrow-derived cells but also ADSCs engrafted in the infarct region 4 weeks after intracoronary cell transplantation and improved cardiac function and perfusion via angiogenesis.
Key Words: Myocardial infarction • Heart failure • Angiogenesis
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EHJ 2007 28: 2565-2567.[Extract] [FREE Full Text]
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