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European Heart Journal Advance Access originally published online on January 24, 2007
European Heart Journal 2007 28(3):334-344; doi:10.1093/eurheartj/ehl450
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Long-term follow-up of primary prophylactic implantable cardioverter-defibrillator therapy in Brugada syndrome

Andrea Sarkozy1,*, Tim Boussy1, Georgios Kourgiannides1, Gian-Battista Chierchia1, Sergio Richter1, Tom De Potter1, Peter Geelen1, Francis Wellens2, Marieke Dingena Spreeuwenberg3 and Pedro Brugada1

1 Cardiovascular Research and Teaching Institute, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
2 Cardiovascular and Thoracic Surgery Department, Aalst, Belgium
3 Department of Clinical Epidemiology and Biostatistics, VU Medical Center, Amsterdam, Holland

Received 14 February 2006; revised 1 November 2006; accepted 30 November 2006; online publish-ahead-of-print 24 January 2007.

* Corresponding author. Tel: +32 53 72 4439; fax: +32 53 72 4185. E-mail address: andreasarkozy{at}yahoo.ca

Aims To analyse the follow-up data of implantable cardioverter-defibrillator (ICD) therapy in Brugada syndrome (BS).

Methods and results We conducted a retrospective, single centre study of 47 patients (mean age: 44.5 ± 15 years) with BS, who underwent primary prophylactic ICD implantation. All patients had baseline spontaneous (23 patients) or drug-induced (24 patients) coved type I ECG pattern. All patients were judged to be at high risk because of syncope (26 patients) and/or a positive family history of sudden death (26 patients). During a median follow-up of 47.5 months, seven patients had appropriate shocks. The presence of spontaneous type I ECG and non-sustained ventricular tachyarrhythmia in the ICD datalog suggested a trend towards shorter appropriate shock-free survival by Kaplan–Meier analysis (P = 0.037 and P = 0.012, respectively). Seventeen patients received inappropriate shocks (IS); eight patients for sinus tachycardia; six patients for new onset atrial arrhythmias; and five patients for noise oversensing. In multivariable Cox-regression analysis, new onset atrial fibrillation (AF) and less than 50 years of age were independent predictors of significantly shorter IS-free survival (P = 0.04 and P = 0.036, respectively).

Conclusion In high-risk patients with BS, primary prophylactic ICD therapy is an effective treatment. In this, young and otherwise healthy patient population, the IS rate is high.

Key Words: Brugada syndrome • Sudden death • ICD therapy


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