European Heart Journal Advance Access originally published online on January 22, 2007
European Heart Journal 2007 28(4):492-498; doi:10.1093/eurheartj/ehl475
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The joint associations of occupational, commuting, and leisure-time physical activity, and the Framingham risk score on the 10-year risk of coronary heart disease
1 Department of Health Promotion and Chronic Diseases Prevention, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland
2 Department of Public Health, University of Helsinki, Helsinki, Finland
3 South Ostrobothnia Central Hospital, Seinäjoki, Finland
4 Tampere School of Public Health, University of Tampere, Tampere, Finland
Received 19 September 2006; revised 22 November 2006; accepted 21 December 2006; online publish-ahead-of-print 22 January 2007.
* Corresponding author. Tel: +358 9 19127366; fax: +358 9 19127313. E-mail address: hu.gang{at}ktl.fi
Aims To determine joint associations of different kinds of physical activity and the Framingham risk score (FRS) with the 10-year risk of coronary heart disease (CHD) events.
Methods and results Study cohorts included 41 053 Finnish participants aged 25–64 years without history of CHD and stroke. The multivariable-adjusted 10-year hazard ratios (HRs) of coronary events associated with low, moderate, and high occupational physical activity were 1.00, 0.66, and 0.74 (Ptrend<0.001) for men, and 1.00, 0.53, and 0.58 (Ptrend<0.001) for women, respectively. The multivariable-adjusted 10-year HRs of coronary events associated with low, moderate, and high leisure-time physical activity were 1.00, 0.97, and 0.66 (Ptrend = 0.002) for men, and 1.00, 0.74, and 0.54 (Ptrend = 0.003) for women, respectively. Active commuting had a significant inverse association with 10-year risk of coronary events in women only. The FRS predicted 10-year risk of coronary events among both men and women. The protective effects of occupational, commuting, or leisure-time physical activity were consistent in subjects with a very low (<6%), low (6–9%), intermediate (10–19%), or high (
20%) risk of the FRS.
Conclusion Moderate or high levels of occupational or leisure-time physical activity among both men and women, and daily walking or cycling to and from work among women are associated with a reduced 10-year risk of CHD events. These favourable effects of physical activity on CHD risk are observed at all levels of CHD risk based on FRS assessment.
Key Words: Exercise • Risk factors • Cardiovascular diseases
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