Skip Navigation


European Heart Journal Advance Access originally published online on March 5, 2007
European Heart Journal 2007 28(6):651-652; doi:10.1093/eurheartj/ehm009
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
28/6/651    most recent
ehm009v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in EHJ
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dawn, B.
Right arrow Articles by Bolli, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dawn, B.
Right arrow Articles by Bolli, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Bone marrow for cardiac repair: the importance of characterizing the phenotype and function of injected cells

Buddhadeb Dawn and Roberto Bolli*

Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA

* Corresponding author. Tel: +1 502 8521837; fax: +1 502 852 6474. E-mail address: rbolli@louisville.edu

This editorial refers to ‘Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction’ {dagger} by F.H. Seeger et al., on page 766

The first 10% of the full text of this article appears below.

Administration of adult stem cells for cardiac repair after myocardial infarction (MI) is a revolutionary new strategy that could become clinically feasible in the near term, appears to be safe and relatively cost-effective, and offers tremendous potential to improve prognosis.1 Using diverse cell populations and strategies, several relatively small clinical studies have reported encouraging outcomes, with improvement in various measures of myocardial perfusion and left ventricular (LV) function.2 However, negative data have also emerged, generating controversy regarding the overall efficacy of cell therapy.2

This controversy persists even after the recent publication of the three largest randomized studies to date of cell therapy for cardiac repair.3–5 In the largest of these trials, the multicentre REPAIR-AMI study,3 204 patients received an intracoronary infusion of autologous mononuclear bone marrow cells (BMCs) or placebo (medium) at 3–7 days . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in EHJ:

Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction
Florian H. Seeger, Torsten Tonn, Nicola Krzossok, Andreas M. Zeiher, and Stefanie Dimmeler
EHJ 2007 28: 766-772. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 BloodHome page
M. Prokopi, G. Pula, U. Mayr, C. Devue, J. Gallagher, Q. Xiao, C. M. Boulanger, N. Westwood, C. Urbich, J. Willeit, et al.
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Blood, July 16, 2009; 114(3): 723 - 732.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. C. Dudley Jr and D. Simpson
An Imperfect Syllogism: Granulocyte Colony-Stimulating Factor Mobilization and Cardiac Regeneration
J. Am. Coll. Cardiol., April 15, 2008; 51(15): 1438 - 1439.
[Full Text] [PDF]