European Heart Journal Advance Access originally published online on April 4, 2007
European Heart Journal 2007 28(8):1012-1018; doi:10.1093/eurheartj/ehm062
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High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides
1 Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands
2 Department of Cardiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
3 Department of Nephrology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
4 Laboratory of Vascular Medicine and Metabolism, Erasmus University Medical Centre, Rotterdam, The Netherlands
5 Department of Cell Biology and Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands
6 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Received 13 March 2006; revised 1 March 2007; accepted 8 March 2007; online publish-ahead-of-print 4 April 2007.
* Corresponding author. Tel: +31 50361 3731; fax: +31 50361 9392. E-mail address: r.p.f.dullaart{at}int.umcg.nl
Aims: High cholesteryl ester transfer protein (CETP) concentrations are associated with increased risk of cardiovascular disease (CVD) in subjects with high triglycerides. We determined the relationship of plasma CETP with incident CVD in a population with relatively low triglycerides.
Methods and results: A nested case–control study was performed in men participating in the prospective PREVEND study, after exclusion of CVD, diabetes mellitus, and lipid-lowering drugs use at baseline. Plasma CETP was measured in 111 men who developed a cardiovascular event (cases) during follow-up and in 116 controls who remained free of CVD. Fasting total cholesterol (P < 0.001) and triglycerides (P < 0.001) were higher, HDL cholesterol was lower (P = 0.001), but CETP was similar in cases and controls (P = 0.39). Cox proportional hazards regression analysis showed that CVD risk tended to be lower with higher plasma CETP after adjustment for age and lipids (hazard ratio 0.84; 95% CI 0.69–1.03, P = 0.10). Plasma CETP was lower in cases than in controls (P = 0.05) with triglycerides 
1.38 mmol/L (median), but not with higher triglycerides. The age-adjusted hazard ratio for CVD was 0.46 (95% CI 0.24–0.90) in men with triglycerides 1.38 mmol/L and CETP > 2.26 mg/L (median) compared with men with similarly low triglycerides and CETP 2.26 mg/L. With higher triglycerides, the hazard ratio for CVD was similar in both CETP categories.
Conclusion: Relatively high plasma CETP may favour reduced CVD risk in the context of low triglycerides.
Key Words: CETP mass • Cardiovascular disease • Triglycerides • Prospective • Case–control study
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