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European Heart Journal Advance Access originally published online on April 18, 2008
European Heart Journal 2008 29(10):1224-1240; doi:10.1093/eurheartj/ehn156
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Diabetes, left ventricular systolic dysfunction, and chronic heart failure

Michael R. MacDonald1,*, Mark C. Petrie1, Nathaniel M. Hawkins2, John R. Petrie3, Miles Fisher1, Robert McKelvie4, David Aguilar5, Henry Krum6 and John J.V. McMurray7

1 Glasgow Royal Infirmary, Glasgow, UK
2 Aintree Cardiac Centre, Liverpool, UK
3 University of Dundee, Dundee, UK
4 McMaster University, Hamilton, Ontario, Canada
5 Baylor College of Medicine, Houston, TX, USA
6 Monash University/Alfred Hospital, Melbourne, Australia
7 Western Infirmary of Glasgow, Glasgow, UK

Received 14 December 2007; revised 3 March 2008; accepted 20 March 2008; online publish-ahead-of-print 18 April 2008.

* Corresponding author: Email: michaelrossmacdonald{at}yahoo.com

Chronic heart failure (HF) and diabetes mellitus (DM) commonly coexist. Each condition increases the likelihood of developing the other, and when they occur together in the same patient the risk of morbidity and mortality increases markedly. We discuss the epidemiological overlap and consider the complex patho-physiological pathways linking the two diseases. The treatment of each condition is made more problematic by the presence of the other. We review the evidence-based treatment strategies and discuss the common problems faced by physicians when treating patients with both conditions. This article forms a comprehensive overview of a fascinating intersection between two common diseases.

Key Words: Diabetes • Heart failure


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