European Heart Journal Advance Access originally published online on January 18, 2008
European Heart Journal 2008 29(11):1446-1453; doi:10.1093/eurheartj/ehm589
Autograft or allograft aortic valve replacement in young adult patients with congenital aortic valve disease
1 Department of Cardio Thoracic Surgery, Bd 571, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, the Netherlands
2 Department of Cardiology, Erasmus University Medical Center Rotterdam, the Netherlands
3 Department of Public Health, Erasmus University Medical Center Rotterdam, the Netherlands
Received 26 June 2007; revised 29 October 2007; accepted 22 November 2007; online publish-ahead-of-print 18 January 2008.
* Corresponding author. Tel: +31 10 4634481, Fax: +31 10 4633993, Email: l.klieverik{at}erasmusmc.nl
Aims: We analysed the outcome of young adults with congenital aortic valve disease who underwent allograft or autograft aortic valve or root replacement in our institution and evaluated whether there is a preference for either valve substitute.
Methods and results: Between 1987 and 2007, 169 consecutive patients with congenital aortic valve disease aged 16–55, participating in our ongoing prospective follow-up study, underwent 63 autograft and 106 allograft aortic valve replacements (AVRs). Mean age was 35 years (SD 10.8), 71% were males. Aetiology was 71% bicuspid valve, 14% other congenital, and 15% BV endocarditis. Twenty-two percent underwent previous cardiac surgery; 11% had an ascending aorta aneurysm. Two patients died in hospital. During follow-up six more patients died and 45 patients required valve-related re-operations. Thirteen-year survival was 97% for autograft and 93% for allograft recipients, 13 year freedom from valve-related re-operation was 63% for autograft and 69% for allograft patients.
Conclusion: In patients with congenital aortic valve disease, autograft and allograft AVR show comparable satisfactory early and long-term results, with the increasing re-operation risk in the second decade after operation remaining a major concern.
Key Words: Aortic valve replacement • Congenital aortic valve disease • Young adults • Prosthetic valve selection • Autograft • Allograft
Presented at the World Congress of Cardiology in Barcelona, Spain, 2–6 September 2006.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Schenke-Layland, U. A. Stock, A. Nsair, J. Xie, E. Angelis, C. G. Fonseca, R. Larbig, A. Mahajan, K. Shivkumar, M. C. Fishbein, et al. Cardiomyopathy is associated with structural remodelling of heart valve extracellular matrix Eur. Heart J., September 2, 2009; 30(18): 2254 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Rahimtoola The Year in Valvular Heart Disease J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1894 - 1908. [Full Text] [PDF]
|
|
|
|
|
|
L. M.A. Klieverik, A. J.J.C. Bogers, and J. J.M. Takkenberg Is the Ross procedure really a Trojan horse: reply Eur. Heart J., September 1, 2008; 29(17): 2181 - 2182. [Full Text] [PDF]
|
|