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European Heart Journal Advance Access originally published online on January 19, 2008
European Heart Journal 2008 29(6):741-747; doi:10.1093/eurheartj/ehm605
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study

Giovanni de Simone1,*, John S. Gottdiener2, Marcello Chinali1 and Mathew S. Maurer3

1 Department of Clinical and Experimental Medicine, Federico II University Hospital, via S.Pansini 5, 80131 Napoli, Italy
2 University of Maryland Hospital, Baltimore, MD, USA
3 Columbia University, New York, NY, USA

Received 28 June 2007; revised 3 December 2007; accepted 6 December 2007; online publish-ahead-of-print 19 January 2008.

* Corresponding author. Tel: +39 81 746 2013, Fax: +39 81 546 6152, Email: simogi{at}unina.it

See page 698 for the editorial comment on this article (doi:10.1093/eurheartj/ehn031)

Aims: The relationship of left ventricular hypertrophy (LVH) to incident heart failure (HF) not attributable to myocardial infarction (MI) has not been defined. We assessed whether LVH is an independent predictor of MI-independent HF.

Methods and results: LVH was assessed by echocardiographic LV mass index (in g/m2.7) and excess of LV mass (eLVM, in % of the observed value) relative to the amount predicted by sex, stroke work, and height, using a prognostically validated equation in 2078 participants of Cardiovascular Health Study without prevalent MI and normal systolic function. Increasing eLVM was associated with progressively increasing left atrial dimension and concentric geometry, decreasing systolic (P < 0.0001), and diastolic function (P < 0.04). After adjustment for age, sex, obesity, diabetes, hypertension, and antihypertensive therapy, and accounting for by incident MI, hazard of HF increased by 1% for each 1% increase in eLVM and by 3% for each g/m2.7 increase in LV mass index (both P < 0.0001). The results were confirmed when also C-reactive protein and measures of systolic (endocardial shortening) and diastolic function (categories of E/A ratio) were added to the Cox models.

Conclusion: In an elderly population, LVH, measured as LV mass index or eLVM is an independent predictor of incident HF not related to prevalent or incident MI.

Key Words: Left ventricular hypertrophy • Echocardiography • Heart failure • Follow-up • Cardiovascular outcome • Excessive left ventricular mass • Population study


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