European Heart Journal Advance Access originally published online on February 9, 2008
European Heart Journal 2008 29(6):827-828; doi:10.1093/eurheartj/ehn014
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
Familial aggregation of left main coronary artery disease and future risk of coronary events in asymptomatic siblings of affected patients: reply
Klinik und Poliklinik für Innere Medizin II
Universität Regensburg
Franz-Josef-Strauss Allee 11
93053 Regensburg
Germany
Email: marcus.fischer@klinik.uni-regensburg.de
Medizinische Klinik II
Universität Schleswig-Holstein, Campus Lübeck
Ratzeburger Allee 160
23538 Lübeck
Germany
Email: heribert.schunkert@innere2.uni-regensburg.de
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We thank Dr Patel et al. for their kind interest in our manuscript. Indeed, we agree with the authors that manifestation of atherosclerosis is anatomically diffuse and as such modulated by several, including heritable, risk factors. Also, their notion that left main disease (LMD) is rarely an isolated phenomenon but rather occurs in