Skip Navigation


European Heart Journal Advance Access originally published online on March 10, 2008
European Heart Journal 2008 29(7):837-839; doi:10.1093/eurheartj/ehn075
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
29/7/837    most recent
ehn075v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in EHJ
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MacFadyen, R. J.
Right arrow Articles by Ng Kam Chuen, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MacFadyen, R. J.
Right arrow Articles by Ng Kam Chuen, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Developing the utility of blood biomarker associations beyond population sample linkage to events in cardiovascular patients

Robert J. MacFadyen* and M. Jennyfer Ng Kam Chuen

University Department of Medicine and Department of Cardiology, City Hospital, Dudley Road, Birmingham B18 7QH, UK

* Corresponding author. Tel: +44 121 507 4476/5080, Fax: +44 121 554 4083, Email: Robert.macfadyen@swbh.nhs.uk {dagger} doi:10.1093/eurheartj/ehn007

This editorial refers to ‘The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study’{dagger} by M.J. West et al., on page 923

Footnotes

The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

The first 10% of the full text of this article appears below.

West et al.1 report a small, well designed post hoc nested case–control sample from the LIPID trial of pravastatin.2 This was completed in low risk subjects with documented coronary disease in the form of a previous confirmed acute coronary syndrome (ACS). This additional report examines biomarker linkage over a relatively short time frame of 2–3 years and highlights two measurements perhaps not intuitively linked to the biology of coronary disease progression. The conditional logistic regression analysis shows a significant linkage association following point analysis for N-terminal brain natriuretic peptide (NT-BNP) and tissue metalloproteinase-1 (TIMP-1). TIMP-1 has been linked to cardiovascular events in low risk patients previously, in patients with less well confirmed coronary disease.3 Its re-affirmation . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in EHJ:

The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study
Malcolm J. West, Paul J. Nestel, Adrienne C. Kirby, Renate Schnabel, David Sullivan, R. John Simes, Christine Pollicino, Edith Lubos, Thomas F. Münzel, Harvey D. White, Andrew M. Tonkin, Christoph Bickel, Laurence Tiret, Stefan Blankenberg, and for the LIPID Study Investigators
EHJ 2008 29: 923-931. [Abstract] [Full Text]