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European Heart Journal Advance Access originally published online on March 18, 2009
European Heart Journal 2009 30(11):1378-1384; doi:10.1093/eurheartj/ehp072
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Socioeconomic status, blood pressure progression, and incident hypertension in a prospective cohort of female health professionals

David Conen1,2,*, Robert J. Glynn1, Paul M. Ridker1,3, Julie E. Buring1 and Michelle A. Albert1,3

1 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
2 Cardiology Division, University Hospital, Petersgraben 4, 4031 Basel, Switzerland
3 Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Received 9 September 2008; revised 17 January 2009; accepted 30 January 2009; online publish-ahead-of-print 18 March 2009.

* Corresponding author. Tel: +41 61 265 25 25, Fax: +41 61 265 45 98, Email: conend{at}uhbs.ch

See page 1305 for the editorial comment on this article (doi:10.1093/eurheartj/ehp131)

Aims: The aim of this study was to examine the association between socioeconomic status, blood pressure (BP) progression, and incident hypertension.

Methods and results: We included 27 207 female health professionals free of hypertension and cardiovascular disease at baseline. Participants were classified into five education and six income categories. The main outcome variables were BP progression at 48 months of follow-up and incident hypertension during the entire study period. At 48 months, 48.1% of women had BP progression. The multivariable adjusted relative risks [95% confidence intervals (CIs)] for BP progression were 1.0 (referent), 0.96 (0.92–1.00), 0.92 (0.88–0.96), 0.90 (0.85–0.94), and 0.84 (0.78–0.91) (P for trend <0.0001) across increasing education categories and 1.0 (referent), 1.01 (0.94–1.08), 0.99 (0.93–1.06), 0.97 (0.91–1.04), 0.96 (0.90–1.03), and 0.89 (0.83–0.96) across increasing income categories (P for trend = 0.0001). During a median follow-up of 9.8 years, 8248 cases of incident hypertension occurred. Multivariable adjusted hazard ratios (95% CI) were 1.0 (referent), 0.92 (0.86–0.99), 0.85 (0.79–0.92), 0.87 (0.80–0.94), and 0.74 (0.65–0.84) (P for trend <0.0001) across increasing education categories and 1.0 (referent), 1.07 (0.95–1.21), 1.07 (0.95–1.20), 1.06 (0.94–1.18), 1.04 (0.93–1.16), and 0.93 (0.82–1.06) (P for trend 0.08) across increasing income categories. In joint analyses, education but not income remained associated with BP progression and incident hypertension.

Conclusion: Socioeconomic status, as determined by education but not by income, is a strong independent predictor of BP progression and incident hypertension in women.

Key Words: Blood pressure • Hypertension • Socioeconomic status • Education • Income


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