Skip Navigation


European Heart Journal Advance Access originally published online on May 24, 2009
European Heart Journal 2009 30(15):1853-1862; doi:10.1093/eurheartj/ehp184
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
30/15/1853    most recent
ehp184v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Unno, K.
Right arrow Articles by Murohara, T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Unno, K.
Right arrow Articles by Murohara, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy

Kazumasa Unno1, Satoshi Isobe1,*, Hideo Izawa1, Xian Wu Cheng1, Masakazu Kobayashi1, Akihiro Hirashiki1, Takashi Yamada1, Ken Harada1, Satoru Ohshima1, Akiko Noda2, Kohzo Nagata2, Katsuhiko Kato3, Mitsuhiro Yokota4 and Toyoaki Murohara1

1 Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
2 Department of Medical Technology, Nagoya University School of Health Science, Nagoya, Japan
3 Department of Radiology, Nagoya University Hospital, Nagoya, Japan
4 Department of Genome Science, Aichi-Gakuin University School of Dentistry, Nagoya, Japan

Received 27 October 2008; revised 27 February 2009; accepted 21 April 2009; online publish-ahead-of-print 24 May 2009.

* Corresponding author. Tel: +81 52 744 2147, Fax: +81 52 744 2138, Email: sisobe{at}med.nagoya-u.ac.jp

Aims: To examine the relation between mitochondrial dysfunction and myocardial contractile and relaxation reserves in hypertrophic cardiomyopathy (HCM).

Methods and results: Thirty HCM patients (LVEF ≥60%) underwent biventricular cardiac catheterization analysis both at rest and during atrial pacing as well as myocardial 99mTc-sestamibi scintigraphy at rest to calculate washout rate. Endomyocardial biopsy specimens were obtained for quantitative mRNA analysis and electron microscopy. The HCM patients were divided into two groups—group A: normal force–frequency relation and a pressure half-time (T1/2) of <30 ms (n = 15); group B: abnormal force–frequency relation or T1/2 of ≥30 ms (n = 15). The 99mTc-sestamibi washout rate was significantly correlated with T1/2 for all patients (r = 0.74, P < 0.01) and was also significantly greater in group B (29.2 ± 6.3%) than in group A (19.3 ± 3.1%). The abundance of mRNAs for mitochondrial electron transport-related enzymes was significantly higher in group A than in group B. Mitochondria showed a greater variation in size and were more disorganized in group B than in group A.

Conclusion: Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients without baseline systolic dysfunction. These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves.

Key Words: Cardiomyopathy • Scintigraphy • Myocardial contractile reserve • Myocardial relaxation reserve • Mitochondria


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.