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European Heart Journal 1984 5(4):338-342;
Copyright © 1984 by the European Society of Cardiology.
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© 1984 The European Society of Cardiology

Effects of cardiac failure on the pharmacokinetics of the diuretic tizolemide

B. BEERMANN1 and C. EDELSTAM

Department of Medicine, S:t Erik's Hospital S-112 82 Stockholm, Sweden

Received 20 May 1983; revised 30 October 1983; .

1Address for correspondence: B. Beermann, MD, Department of Medicine, S:t Erik's Hospital. S-l 12 82 Stockholm, Sweden.

Abstract

Tizolemide, an alkaline sulphonamide diuretic, was given i.v. in one dose and orally during one week to eight patients with compensated cardiac failure. They had essentially normal glomerular filtration rate but reduced renal plasma flow.

Tizolemide was almost completely absorbed from the gastrointestinal tract. The drug was mainly eliminated via tubular secretion. Renal clearance of the drug was much lower than in healthy subjects because of low renal plasma flow. As a consequence plasma half–life was prolonged considerably in some patients.

It was concluded that drugs with mainly tubular renal elimination may have a reduced elimination rate in patients with cardiac diseases despite normal glomerular filtration rate.

Key Words: Cardiac failure • diuretics • renal clearance • tubular secretion


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