European Heart Journal Advance Access published online on November 30, 2004
European Heart Journal, doi:10.1093/eurheartj/ehi003
Copyright © 2004 by the European Society of Cardiology.
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1 Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany; GSF, Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
* To whom correspondence should be addressed. Aims To investigate the association between apolipoprotein B (apoB), A-I (apoA-I), the apoB/apoA-I ratio, and the incidence of coronary events. Methods and results Analysis included 1414 men and 1436 women aged 35-64 years without a prior coronary event who participated in the population-based MONICA Augsburg survey 1984-85 (median followed-up period 13 years). Incidence of fatal and non-fatal myocardial infarction, and sudden cardiac death was assessed using data of the MONICA/KORA Augsburg coronary event registry. During follow-up, 114 incident coronary events occurred in men and 31 in women. In multivariable analysis, an increase of 1 standard deviation in the serum concentration of apoB was associated with an increased risk of coronary events in men [hazard ratio (HR) = 1.49; 95% confidence interval (CI); 1.25-1.78] and in women (HR = 1.73; 95% CI; 1.32-2.27). By contrast, elevated concentrations of apoA-I were not associated with a significantly decreased risk of coronary events in either sex (HR=0.91). Furthermore, the predictive power of the apoB/apoA-I ratio was similar to that of the total cholesterol/HDL cholesterol ratio in men and women. Conclusion ApoB and the apoB/apoA-I ratio were strong predictors of coronary events in middle-aged men and women, whereas apoA-I did not add significantly to the estimation of future coronary risk.
Preclinical research
Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study
2 Klinikum der Universität München, Institute of Clinical Chemistry, Munich, Germany
3 Department of Internal Medicine II--Cardiology, University of Ulm Medical Center, Ulm, Germany
Wolfgang Koenig, E-mail: wolfgang.koenig{at}medizin.uni-ulm.de
Abstract 
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