Skip Navigation



European Heart Journal Advance Access published online on December 16, 2004
European Heart Journal, doi:10.1093/eurheartj/ehi037
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/6/617    most recent
ehi037v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Meyer, A.A.
Right arrow Articles by Kienast, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyer, A.A.
Right arrow Articles by Kienast, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2004; all rights reserved.

Clinical research

Predicting the risk of early atherosclerotic disease development in children after repair of aortic coarctation

A.A. Meyer 1*, M.S. Joharchi 2, G. Kundt 3, P. Schuff-Werner 4, G. Steinhoff 2, and W. Kienast 5

1 Department of Pediatric Cardiology, University of Rostock, Germany; Universitäts- Kinder- und Jugendklinik Rostock, Rembrandtstraße 16-17, 18055 Rostock, Germany
2 Department of Cardiac Surgery, University of Rostock, Germany
3 Department of Medical Informatics and Biometry, University of Rostock, Germany
4 Department of Laboratory Medicine, University of Rostock, Germany
5 Department of Pediatric Cardiology, University of Rostock, Germany

* To whom correspondence should be addressed.
A.A. Meyer, E-mail: andreas-alexander.meyer{at}medizin.uni-rostock.de


  Abstract

Aims Increased cardiovascular morbidity is manifested a long time after the repair of aortic coarctation (CoA). By way of impaired flow-mediated vasodilation (FMD) and increased intima media thickness (IMT), surrogate parameters of atherosclerosis, cardiovascular risk factors (RFs) can be correlated with early vascular wall changes in children. This study investigated whether changes in arterial wall function and morphology are detectable in children after coarctation repair.

Methods and results We examined 28 children after successful repair of CoA vs. 30 control subjects. All children underwent identical screening, with a broad RF profile and FMD/IMT measurements. CoA-children presented significantly (P < 0.001) impaired FMD (4.87 ± 2.6 vs. 10.2 ± 3.1%) and higher IMT values (P < 0.001) than the controls (0.48 ± 0.08 vs. 0.38 ± 0.05mm). The blood pressure during rest and exercise and the left ventricular mass were significantly elevated, but no additional RF could be identified in CoA-children. Only a remaining pressure gradient related significantly to FMD.

Conclusion This study documents early vascular wall changes in children after successful coarctation repair. Arterial hypertension and a resting pressure gradient are the major contributing factors to early atherosclerotic development and should be primary targets for therapy. Vascular status should be monitored regularly by FMD and IMT.

Keywords: Atherosclerosis; Paediatrics; Aortic coarctation; Risk factors.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HeartHome page
Y-Y Lam, M J Mullen, M G Kaya, M A Gatzoulis, W Li, and M Y Henein
Left ventricular long axis dysfunction in adults with "corrected" aortic coarctation is related to an older age at intervention and increased aortic stiffness
Heart, May 1, 2009; 95(9): 733 - 739.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. Brili, D. Tousoulis, C. Antoniades, C. Vasiliadou, M. Karali, N. Papageorgiou, N. Ioakeimidis, K. Marinou, E. Stefanadi, and C. Stefanadis
Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta A Randomized Cross-Over Study.
J. Am. Coll. Cardiol., February 19, 2008; 51(7): 742 - 749.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
N. M. Pinto, B. S. Marino, G. Wernovsky, S. D. de Ferranti, A. Z. Walsh, M. Laronde, K. Hyland, S. O. Dunn Jr, and M. S. Cohen
Obesity Is a Common Comorbidity in Children With Congenital and Acquired Heart Disease
Pediatrics, November 1, 2007; 120(5): e1157 - e1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Hager, S. Kanz, H. Kaemmerer, C. Schreiber, and J. Hess
Coarctation Long-term Assessment (COALA): Significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material
J. Thorac. Cardiovasc. Surg., September 1, 2007; 134(3): 738 - 745.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. Ou, D. S. Celermajer, E. Mousseaux, A. Giron, Y. Aggoun, I. Szezepanski, D. Sidi, and D. Bonnet
Vascular Remodeling After "Successful" Repair of Coarctation: Impact of Aortic Arch Geometry
J. Am. Coll. Cardiol., February 27, 2007; 49(8): 883 - 890.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. A. Meyer, G. Kundt, U. Lenschow, P. Schuff-Werner, and W. Kienast
Improvement of Early Vascular Changes and Cardiovascular Risk Factors in Obese Children After a Six-Month Exercise Program
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1865 - 1870.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. A. Meyer, G. Kundt, M. Steiner, P. Schuff-Werner, and W. Kienast
Impaired Flow-Mediated Vasodilation, Carotid Artery Intima-Media Thickening, and Elevated Endothelial Plasma Markers in Obese Children: The Impact of Cardiovascular Risk Factors
Pediatrics, May 1, 2006; 117(5): 1560 - 1567.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.