European Heart Journal Advance Access published online on December 15, 2004
European Heart Journal, doi:10.1093/eurheartj/ehi070
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1 Hypertension and Cardiovascular Prevention Centre, ASL n.1-University of Sassari, Italy
* To whom correspondence should be addressed. Aims Left ventricular mass (LVM) is under the control of aldosterone and angiotensin II in experimental hypertension, but the effect of aldosterone on LVM is controversial in essential hypertension (EH). Some EH patients show a mild impairment of 11 Methods and results The ratio between 24h urinary tetrahydro derivatives of cortisol and cortisone (THFs/THE), plasma renin activity, 24 h urinary aldosterone, blood pressure, and LVM indexed for height2.7 (LVMh2.7) were analysed in 493 never-treated hypertensives and 98 normotensives. THFs/THE was associated with LVMh2.7 in hypertensives and normotensives (r = 0.32, P < 0.001, and r = 0.17, P = 0.04, respectively) and persisted after adjusting for confounders (multiple regression analysis). Body mass index, sex, recumbent plasma renin activity, and THFs/THE accounted for 26.1% of LVMh2.7 variation. Urinary aldosterone was not correlated with LVMh2.7. Conclusion We suggest that glucocorticoids may take part in the regulation of LVM in EH patients as a function of 11
Clinical research
11
-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertension
2 Emergency Department, ASL n.1, Sassari, Italy
3 Hypertension Centre, University of Torino, Italy
Nicola Glorioso, E-mail: glorioso{at}uniss.it
Abstract 
-hydroxysteroid dehydrogenase type 2 (11-HSD2) activity without clinical features of the syndrome of apparent mineralocorticoid excess, where the incomplete cortisol-to-cortisone conversion leads to glucocorticoid-mediated mineralocorticoid effects. The mineralocorticoid receptor and 11-HSD2 are co-expressed in human heart. We investigated whether LVM may be regulated by glucocorticoids in EH patients.-HSD2 activity, and contribute to the target organ damage associated with essential hypertension.-Hydroxysteroid dehydrogenase; Mineralocorticoids; Glucocorticoids; Blood pressure.
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