Skip Navigation



European Heart Journal Advance Access published online on January 28, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi110
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/7/662    most recent
ehi110v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by De Luca, G.
Right arrow Articles by Suryapranata, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Luca, G.
Right arrow Articles by Suryapranata, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved

Clinical research

Ageing, impaired myocardial perfusion, and mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty

Giuseppe De Luca 1, Arnoud W.J. van t'Hof 1, Jan Paul Ottervanger 1, Jan C.A. Hoorntje 1, A. T. Marcel Gosselink 1, Jan-Henk E. Dambrink 1, Menko-Jan de Boer 1, and Harry Suryapranata 1*

1 Department of Cardiology, ISALA Klinieken, Hospital De Weezenlanden, Groot Weezelanden 20, 8011 JW Zwolle, The Netherlands

* To whom correspondence should be addressed.
Harry Suryapranata, E-mail: h.suryapranata{at}diagram-zwolle.nl


  Abstract

Aims It is still unknown whether impaired myocardial perfusion helps to explain the higher mortality observed with ageing in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary angioplasty.

Methods and results In 1548 consecutive patients with STEMI treated with primary angioplasty, myocardial perfusion was evaluated by myocardial blush grade (MBG) and ST-segment resolution. All clinical and follow-up data were prospectively collected. Advanced age was associated with a significantly higher clinical and angiographic risk profile. We found a linear relationship between increasing age, decreased myocardial perfusion, and higher 1-year mortality. After adjustment for baseline potential confounding variables, increased age was still significantly associated with impaired myocardial blush (MBG 0-1) (P = 0.028), and ST-segment resolution (<50%) (P = 0.007). At multivariable analysis both age (P < 0.0001) and poor myocardial perfusion (P < 0.0001) were independent predictors of 1-year mortality.

Conclusion This study shows that impaired reperfusion is an additional determinant of the poor outcome observed with advanced age in patients with STEMI undergoing mechanical revascularization.

Keywords: Primary angioplasty; Perfusion; Ageing; Mortality.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HeartHome page
L De Luca, G Sardella, C J Davidson, G De Persio, M Beraldi, T Tommasone, M Mancone, B L Nguyen, L Agati, M Gheorghiade, et al.
Impact of intracoronary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation myocardial infarction
Heart, July 1, 2006; 92(7): 951 - 957.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
S. Agewall
How should we evaluate an open artery in STEMI patients?
Eur. Heart J., April 1, 2005; 26(7): 634 - 636.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.