European Heart Journal Advance Access published online on February 23, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi135
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1 Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, 3010 Bern, Switzerland
* To whom correspondence should be addressed. Aims To investigate the efficacy and outcome of emergency percutaneous coronary interventions (PCI) in patients with stent thrombosis. Methods and results Between 1995 and 2003, 6058 patients underwent bare-metal stent implantation, of which 95 (1.6%) patients suffered from stent thrombosis. The timing of stent thrombosis was acute in 10 (11%), subacute in 61 (64%), and late in 24 (25%) patients. Procedural and clinical outcomes of emergency PCI for treatment of stent thrombosis were investigated. Emergency PCI was successful in 86 (91%), complicated by death in 2 (2%), and coronary artery bypass grafting in 2 (2%) patients. Myocardial infarction occurred in 77 (81%) patients with a peak creatine kinase level of 1466 ± 1570 U/L. Left ventricular ejection fraction declined from 0.54 ± 0.19 prior to 0.48 ± 0.16 (P < 0.05) at the time of stent thrombosis after emergency PCI. A 6 month major adverse clinical events comprised death (11%), reinfarction (16%), and recurrent stent thrombosis (12%) after emergency PCI. Multivariable logistic regression analysis identified the achievement of TIMI 3 flow (OR = 0.1, CI 95% 0.01-0.54, P < 0.001) and diameter stenosis <50% (OR = 0.06, CI 95% 0.01-0.32, P < 0.001) during emergency PCI to be independently associated with a reduced risk of cardiac death. Recurrent stent thrombosis was independently predicted by the omission of abciximab (OR = 4.3, CI 95% 1.1-17.5). Conclusion Emergency PCI for treatment of stent thrombosis effectively restores vessel patency and flow. Patients presenting with stent thrombosis are at risk for recurrent myocardial infarction and recurrent stent thrombosis.
Clinical research
Stent thrombosis following bare-metal stent implantation: success of emergency percutaneous coronary intervention and predictors of adverse outcome
Stephan Windecker, E-mail: stephan.windecker{at}insel.ch
Abstract 
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