Skip Navigation



European Heart Journal Advance Access published online on April 7, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi191
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/11/1056    most recent
ehi191v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ge, L.
Right arrow Articles by Colombo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ge, L.
Right arrow Articles by Colombo, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received October 31, 2004
Revised January 31, 2005
Accepted February 3, 2005

Clinical research

Immediate and mid-term outcomes of sirolimus-eluting stent implantation for chronic total occlusions

Lei Ge 1, Ioannis Iakovou 2, John Cosgrave 2, Alaide Chieffo 2, Matteo Montorfano 2, Iassen Michev 2, Flavio Airoldi 2, Mauro Carlino 2, Gloria Melzi 2, Giuseppe M. Sangiorgi 2, Nicola Corvaja 2, and Antonio Colombo 3*

1 EMO Centro Cuore Columbus and San Raffaele Hospital, 48 Via M. Buonarroti, 20145 Milan, Italy; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China
2 EMO Centro Cuore Columbus and San Raffaele Hospital, 48 Via M. Buonarroti, 20145 Milan, Italy
3 EMO Centro Cuore Columbus and San Raffaele Hospital, 48 Via M. Buonarroti, 20145 Milan, Italy

* To whom correspondence should be addressed.
Antonio Colombo, E-mail: info{at}emocolumbus.it


  Abstract

Aims To evaluate the outcomes of sirolimus-eluting stent (SES) implantation for the treatment of chronic total occlusion (CTO).

Methods and results We identified 122 patients who underwent revascularization in CTO lesions with SES from April 2002 to April 2004 (SES group). A control group was composed of 259 consecutive patients with CTO lesions treated with bare metal stents (BMS) in the 24 months immediately before the introduction of SES (BMS group). At 6-month follow-up, the cumulative rate of major adverse cardiac events (MACE) was 16.4% in the SES group and 35.1% in the BMS group (P<0.001). The incidence of restenosis was 9.2% in the SES group and 33.3% in the BMS group (P<0.001). The need for revascularization in the SES group was significantly lower, both target lesion revascularization (7.4 vs. 26.3%, P<0.001) and target vessel revascularization (9.0 vs. 29.0%, P<0.001). BMS implantation (HR: 2.97; 95% CI: 1.80-4.89; P<0.001), lesion length (>20 mm) (HR: 2.02; 95% CI: 1.37-2.99; P=0.0004), and baseline reference vessel diameter (>2.8 mm) (HR: 0.62; 95% CI: 0.42-0.92; P=0.02) were identified as predictors of MACE during 6-month follow-up.

Conclusion Compared with BMS, SES implantation in CTO lesions appears to be effective in reducing the incidence of restenosis and the need for revascularization at 6 months.

Keywords: Stents; Occlusion; Angioplasty; Revascularization; Restenosis.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Circ Cardiovasc IntervHome page
A. S.P. Sharp, A. Latib, A. Ielasi, C. Larosa, C. Godino, M. Saolini, V. Magni, R. T. Gerber, M. Montorfano, M. Carlino, et al.
Long-Term Follow-Up on a Large Cohort of "Full-Metal Jacket" Percutaneous Coronary Intervention Procedures
Circ Cardiovasc Interv, October 1, 2009; 2(5): 416 - 422.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol IntvHome page
C. A. Thompson, J. E. Jayne, J. F. Robb, B. J. Friedman, A. V. Kaplan, B. D. Hettleman, N. W. Niles, and W. L. Lombardi
Retrograde Techniques and the Impact of Operator Volume on Percutaneous Intervention for Coronary Chronic Total Occlusions: An Early U.S. Experience
J. Am. Coll. Cardiol. Intv., September 1, 2009; 2(9): 834 - 842.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
H. Ishii, Y. Kumada, T. Toriyama, T. Aoyama, H. Takahashi, T. Amano, Y. Yasuda, Y. Yuzawa, S. Maruyama, S. Matsuo, et al.
Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis
Nephrol. Dial. Transplant., May 1, 2009; 24(5): 1562 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol IntvHome page
D. E. Kandzari, S. V. Rao, J. W. Moses, V. Dzavik, B. H. Strauss, M. J. Kutryk, C. A. Simonton, J. Garg, Y. Lokhnygina, G.B. J. Mancini, et al.
Clinical and Angiographic Outcomes With Sirolimus-Eluting Stents in Total Coronary Occlusions: The ACROSS/TOSCA-4 (Approaches to Chronic Occlusions With Sirolimus-Eluting Stents/Total Occlusion Study of Coronary Arteries-4) Trial
J. Am. Coll. Cardiol. Intv., February 1, 2009; 2(2): 97 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. Valenti, A. Migliorini, U. Signorini, R. Vergara, G. Parodi, N. Carrabba, G. Cerisano, and D. Antoniucci
Impact of complete revascularization with percutaneous coronary intervention on survival in patients with at least one chronic total occlusion
Eur. Heart J., October 1, 2008; 29(19): 2336 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol IntvHome page
A. S.H. Cheng, J. B. Selvanayagam, M. Jerosch-Herold, W. J. van Gaal, T. D. Karamitsos, S. Neubauer, and A. P. Banning
Percutaneous treatment of chronic total coronary occlusions improves regional hyperemic myocardial blood flow and contractility insights from quantitative cardiovascular magnetic resonance imaging.
J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 44 - 53.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Colombo and A. Chieffo
Drug-Eluting Stent Update 2007: Part III: Technique and Unapproved/Unsettled Indications (Left Main, Bifurcations, Chronic Total Occlusions, Small Vessels and Long Lesions, Saphenous Vein Grafts, Acute Myocardial Infarctions, and Multivessel Disease)
Circulation, September 18, 2007; 116(12): 1424 - 1432.
[Full Text] [PDF]

Home page
 JAMAHome page
H. K. Win, A. E. Caldera, K. Maresh, J. Lopez, C. S. Rihal, M. A. Parikh, J. F. Granada, S. Marulkar, D. Nassif, D. J. Cohen, et al.
Clinical Outcomes and Stent Thrombosis Following Off-Label Use of Drug-Eluting Stents
JAMA, May 9, 2007; 297(18): 2001 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Prasad, C. S. Rihal, R. J. Lennon, H. J. Wiste, M. Singh, and D. R. Holmes Jr
Trends in Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusions: A 25-Year Experience From the Mayo Clinic
J. Am. Coll. Cardiol., April 17, 2007; 49(15): 1611 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. Di Giammarco, M. Pano, M. Giancane, A. Di Francesco, and M. Di Mauro
Off-Pump Revascularization of Chronically Occluded Left Anterior Descending Artery Through Left Anterior Small Thoracotomy: Early and Late Angiographic and Clinical Follow-Up.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1446 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. J. Suttorp, G. J. Laarman, B. M. Rahel, J. C. Kelder, M. A.R. Bosschaert, F. Kiemeneij, J. M. ten Berg, E. T. Bal, B. J. Rensing, F. D. Eefting, et al.
Primary Stenting of Totally Occluded Native Coronary Arteries II (PRISON II): A Randomized Comparison of Bare Metal Stent Implantation With Sirolimus-Eluting Stent Implantation for the Treatment of Total Coronary Occlusions
Circulation, August 29, 2006; 114(9): 921 - 928.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. T.L. Ong and P. W. Serruys
Complete Revascularization: Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention
Circulation, July 18, 2006; 114(3): 249 - 255.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Jorgensen and H. Kelbaek
Drug-eluting stents for chronic total occlusions make sense, but it is too early to close the discussion
Eur. Heart J., June 1, 2005; 26(11): 1049 - 1051.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.