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European Heart Journal Advance Access published online on April 8, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi228
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received October 20, 2004
Revised January 26, 2005
Accepted February 17, 2005

Clinical research

Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention

Kenichiro Arakawa 1, Yasuyuki Kawai 1, Teruhiko Kumamoto 1, Norihiro Morikawa 1, Masahiro Yoshida 1, Hiroshi Tada 2, Ren Kawaguchi 2, Koichi Taniguchi 2, Isamu Miyamori 1, Yoshihiko Kominato 3, Koichiro Kishi 3, and Toshihiro Yasuda 4*

1 Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
2 Division of Cardiology, Gunma Prefecture Cardiovascular Centre, Gunma, Japan
3 Department of Legal Medicine, Gunma University Graduate School of Medicine, Gunma, Japan
4 Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan

* To whom correspondence should be addressed.
Toshihiro Yasuda, E-mail: tyasuda{at}fmsrsa.fukui-med.ac.jp


  Abstract

Aims Cardiac markers such as troponin T (c-TnT) have proven unsuitable for the detection of early and transient myocardial ischaemia. We recently reported that abrupt elevation of serum deoxyribonuclease I (DNase I) activity in the early stage of acute myocardial infarction could be used as a diagnostic marker. To evaluate whether serum DNase I could be used as a marker of early myocardial ischaemia, we investigated alterations in its levels after transient ischaemia induced during percutaneous coronary intervention (PCI).

Methods and results In 24 consecutive patients with stable angina undergoing elective PCI and 12 patients undergoing coronary angiography (CAG), serum samples were tested for DNase I, creatine kinase isoenzyme MB (CK-MB), and c-TnT before, soon after, and 3 and 12-24 h after completion of the procedures. Serum DNase I activity had risen significantly from baseline by 3 h after PCI in 21 of the 24 PCI patients. The mean per cent difference from baseline in serum DNase I activity 3 h after PCI was 35.9±37.5%. Even among the 16 PCI patients whose levels of CK-MB and c-TnT were within the normal range, 13 showed elevation of serum DNase I activity from baseline after PCI. In the CAG patient group, DNase I activity levels remained unchanged at all times after CAG.

Conclusion Elevation of serum DNase I activity can be used as a sensitive marker for detection of transient myocardial ischaemia.

Keywords: Angioplasty; Ischaemia; Deoxyribonuclease I.
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