Skip Navigation



European Heart Journal Advance Access published online on April 21, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi271
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/12/1205    most recent
ehi271v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sasso, F. C.
Right arrow Articles by Cozzolino, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasso, F. C.
Right arrow Articles by Cozzolino, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received July 2, 2004
Revised February 18, 2005
Accepted March 17, 2005

Clinical research

Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects

Ferdinando C. Sasso 1*, Ornella Carbonara 1, Rodolfo Nasti 1, Raffaele Marfella 1, Katherine Esposito 1, Pierfrancesco Rambaldi 2, Luigi Mansi 2, Teresa Salvatore 1, Roberto Torella 1, and Domenico Cozzolino 1

1 Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy; Excellence Centre for Cardiovascular Disease, Second University of Naples, Naples, Italy
2 Institute of Nuclear Medicine, Faculty of Medicine, Second University of Naples, Naples, Italy; Excellence Centre for Cardiovascular Disease, Second University of Naples, Naples, Italy

* To whom correspondence should be addressed.
Ferdinando C. Sasso, E-mail: ferdinando.sasso{at}unina2.it


  Abstract

Aims We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise.

Methods and results The cardiac function of 62 normal glucose tolerant subjects, aged 30-40 and divided into normal weight (group 1, n = 22, BMI 20-24.9 kg/m2), overweight (group 2, n = 20, BMI 25-29.9 kg/m2), and obesity (group 3, n = 20, BMI 30-35 kg/m2) was evaluated at rest and during dynamic exercise through angiocardioscintigraphy, when on hyperinsulinaemic euglycaemic clamp (test A) and when on normal saline infusion (test B). Left ventricular function at rest was statistically greater (P < 0.05) in both tests in overweight and obese subjects compared with normal weight controls, with no statistical difference (P = 0.057) within groups between insulin and normal saline infusion. During exercise, cardiac function improved in all the subjects in both tests. The increase was lower in overweight and obese patients, even if statistically significant only in obese vs. control subjects in both tests (P < 0.05). Insulin sensitivity showed a significant correlation (P ≤ 0.001) with left ventricular ejection fraction (LVEF) at rest and with change in LVEF during clamp.

Conclusion Our findings suggest a metabolic pathogenesis for the impaired LV function in obesity.

Keywords: Insulin; Obesity; Left ventricular function; Angiocardioscintigraphy; Exercise.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
D. Barker, S. G. Williams, H. McLoughlin, and L.-B. Tan
Impaired left ventricular function in obesity?
Eur. Heart J., December 2, 2005; 26(24): 2742 - 2742.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
O. Carbonara, R. Torella, and F. C. Sasso
Impaired left ventricular function in obesity?: reply
Eur. Heart J., December 2, 2005; 26(24): 2742 - 2743.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
W. A. Parsonage and D. B. Ojji
Getting to the heart of obesity
Eur. Heart J., June 2, 2005; 26(12): 1150 - 1151.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.