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European Heart Journal Advance Access published online on April 26, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi282
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received December 8, 2004
Revised March 3, 2005
Accepted March 24, 2005

Review

Dendritic cells in atherosclerosis: current status of the problem and clinical relevance

Yuri V. Bobryshev 1*

1 Surgical Professorial Unit, Level 5, DeLacy Building, St Vincent's Hospital Sydney, University of New South Wales, Darlinghurst, New South Wales 2010, Australia

* To whom correspondence should be addressed.
Yuri V. Bobryshev, E-mail: y.bobryshev{at}unsw.edu.au


  Abstract

Dendritic cells (DCs) are the most potent antigen-presenting cells. DCs were identified in arteries in 1995 and, since then, further knowledge has been gained indicating the importance of DCs in atherosclerosis. Vascular DCs have been shown to become activated from a very early stage of atherosclerosis. Some DCs cluster with T cells directly within atherosclerotic lesions, while others migrate to lymphoid organs to activate T cells. Dyslipidaemia systemically alters DC function and recent findings suggest that DCs play a role in plaque destabilization. This review summarizes the current status of the problem.

Keywords: Dendritic cells; Arteries; Atherosclerosis; Plaque destabilization.
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