European Heart Journal Advance Access published online on April 28, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi289
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Section of Cardiology, University of Ferrara and Cardiovascular Research Centre, Arcispedale S. Anna C.rso Giovecca 203, 44100 Ferrara, Italy
* To whom correspondence should be addressed. Aims There is increasing evidence that stem cell (SC) mobilization to the heart and their differentiation into cardiac cells is a naturally occurring process. We sought to assess the safety and feasibility of granulocyte-colony stimulating factor (G-CSF) administration in humans to enhance SC mobilization and left ventricle (LV) injury repair during myocardial infarction (MI). Methods and results Twenty patients with STEMI (mean age, 61 ± 10 years), of whom 14 were submitted to primary percutaneous coronary intervention, were randomized to G-CSF (5 µg/kg/day s.c. for 4 consecutive days) or placebo. At entry and then at months 3 and 6, 99mTc-sestamibi gated-SPECT was performed to estimate extension of perfusion defect (PD) and LV function. The study drug was well tolerated and induced a significant increase of white blood count, CD34+ cells, and CD34+ cells coexpressing AC133 and VEGFR-2. At follow-up, treated and placebo groups did not differ for the angiographic coronary late loss and showed a similar pattern of PD recovery, whereas in the former at 6 months LVEF and especially LVEDV tended to be relatively higher (P = 0.068) and lower (P = 0.054), respectively. Conclusion G-CSF administration in acute MI patients was feasible and did not lead to any clinical or angiographic adverse events and resulted in CD34+ and CD34+AC133+VEGFR2+ cell mobilization.
Received November 5, 2004
Revised February 28, 2005
Accepted March 24, 2005
Clinical research
Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile
2 Section of Hematology, University of Ferrara, Ferrara, Italy
3 Section of Nuclear Medicine, University of Ferrara, Ferrara, Italy
4 Third Laboratory, Spedali Civili, Brescia, Italy
Marco Valgimigli, E-mail: vlgmrc{at}unife.it
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y-J Kim, J-I Shin, K-W Park, H-Y Lee, H-J Kang, B-K Koo, B-J Park, D-W Sohn, B-H Oh, Y-B Park, et al. The effect of granulocyte-colony stimulating factor on endothelial function in patients with myocardial infarction Heart, August 15, 2009; 95(16): 1320 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Kang and H.-S. Kim Safety and efficacy of intracoronary infusion of mobilized peripheral blood stem cell in patients with myocardial infarction: MAGIC Cell-1 and MAGIC Cell-3-DES-trials Eur. Heart J. Suppl., December 1, 2008; 10(suppl_K): K39 - K43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Valgimigli, G. G.L. Biondi-Zoccai, P. Malagutti, A. M. Leone, and A. Abbate Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after myocardial infarction Eur. Heart J. Suppl., December 1, 2008; 10(suppl_K): K27 - K34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Povsic and P. J. Goldschmidt-Clermont Review: Endothelial progenitor cells: markers of vascular reparative capacity Therapeutic Advances in Cardiovascular Disease, June 1, 2008; 2(3): 199 - 213. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Smart and P. R. Riley The Stem Cell Movement Circ. Res., May 23, 2008; 102(10): 1155 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Ince, M Valgimigli, M Petzsch, J S. de Lezo, F Kuethe, S Dunkelmann, G Biondi-Zoccai, and C A Nienaber Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: systematic review and meta-analysis Heart, May 1, 2008; 94(5): 610 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zohlnhofer, A. Dibra, T. Koppara, A. de Waha, R. S. Ripa, J. Kastrup, M. Valgimigli, A. Schomig, and A. Kastrati Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor for Myocardial Recovery After Acute Myocardial Infarction: A Meta-Analysis J. Am. Coll. Cardiol., April 15, 2008; 51(15): 1429 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tongers and D. W. Losordo Frontiers in Nephrology: The Evolving Therapeutic Applications of Endothelial Progenitor Cells J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2843 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-F. Tse and C.-P. Lau Therapeutic Angiogenesis With Bone Marrow--Derived Stem Cells Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2007; 12(2): 89 - 97. [Abstract] [PDF]
|
|
|
|
 |
|
 D. J. Prockop and S. D. Olson Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions Blood, April 15, 2007; 109(8): 3147 - 3151. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Berry, K. P. Balachandran, P. L. L'Allier, J. Lesperance, R. Bonan, and K. G. Oldroyd Importance of collateral circulation in coronary heart disease Eur. Heart J., February 1, 2007; 28(3): 278 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Gibbons, P. A. Araoz, and E. E. Williamson The Year in Cardiac Imaging J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2324 - 2339. [Full Text] [PDF]
|
|
|
|
|
|
J. Kastrup, R. S. Ripa, Y. Wang, and E. Jorgensen Myocardial regeneration induced by granulocyte-colony-stimulating factor mobilization of stem cells in patients with acute or chronic ischaemic heart disease: a non-invasive alternative for clinical stem cell therapy? Eur. Heart J., December 1, 2006; 27(23): 2748 - 2754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A M Leone, L Galiuto, S Rutella, M B Giannico, S Brugaletta, B Garramone, V De Stefano, G Liuzzo, M L Calcagni, F Cirillo, et al. Safety of granulocyte-colony-stimulating factor in acute myocardial infarction (the Rigenera study) Heart, December 1, 2006; 92(12): 1850 - 1851. [Full Text] [PDF]
|
|
|
|
|
|
H. Ince, T. C. Rehders, S. Kische, S. Drawert, E. Adolf, T. Kleinfeldt, M. Petzsch, and C. A. Nienaber G-CSF in the setting of acute myocardial infarction Eur. Heart J. Suppl., December 1, 2006; 8(suppl_H): H40 - H45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sprigg, P. M. Bath, L. Zhao, M. R. Willmot, L. J. Gray, M. F. Walker, M. S. Dennis, and N. Russell Granulocyte-Colony-Stimulating Factor Mobilizes Bone Marrow Stem Cells in Patients With Subacute Ischemic Stroke: The Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092) Stroke, December 1, 2006; 37(12): 2979 - 2983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Shepherd, B. J. Capoccia, S. M. Devine, J. DiPersio, K. M. Trinkaus, D. Ingram, and D. C. Link Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100 Blood, December 1, 2006; 108(12): 3662 - 3667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Engelmann, H. D. Theiss, C. Hennig-Theiss, A. Huber, B. J. Wintersperger, A.-E. Werle-Ruedinger, S. O. Schoenberg, G. Steinbeck, and W.-M. Franz Autologous Bone Marrow Stem Cell Mobilization Induced by Granulocyte Colony-Stimulating Factor After Subacute ST-Segment Elevation Myocardial Infarction Undergoing Late Revascularization: Final Results From the G-CSF-STEMI (Granulocyte Colony-Stimulating Factor ST-Segment Elevation Myocardial Infarction) Trial J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1712 - 1721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ben-Dor, S. Fuchs, and R. Kornowski Potential Hazards and Technical Considerations Associated With Myocardial Cell Transplantation Protocols for Ischemic Myocardial Syndrome J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1519 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lehrke, R. Mazhari, D. J. Durand, M. Zheng, D. Bedja, J. M. Zimmet, K. H. Schuleri, A. S. Chi, K. L. Gabrielson, and J. M. Hare Aging Impairs the Beneficial Effect of Granulocyte Colony-Stimulating Factor and Stem Cell Factor on Post-Myocardial Infarction Remodeling Circ. Res., September 1, 2006; 99(5): 553 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pagliaro Post-infarct heart repair with granulocyte-colony stimulating factor: Is it a utopian goal? Cardiovasc Res, August 1, 2006; 71(3): 405 - 407. [Full Text] [PDF]
|
|
|
|
|
|
P. S.M., M. T., S. A., Y. H.T., C. D., K. S.A., S. V.P., W. B., L. P.S., T. S.M., et al. Leaking Capillaries and White Lung in Sepsis--Is Angiopoietin 2 the Culprit?: Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans. PLoS Medicine 3: e46, 2006 J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1207 - 1217. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Deindl, M.-M. Zaruba, S. Brunner, B. Huber, U. Mehl, G. Assmann, I. E. Hoefer, J. Mueller-Hoecker, and W.-M. Franz G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis FASEB J, May 1, 2006; 20(7): 956 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Hill and J. Bartunek The End of Granulocyte Colony-Stimulating Factor in Acute Myocardial Infarction?: Reaping the Benefits Beyond Cytokine Mobilization Circulation, April 25, 2006; 113(16): 1926 - 1928. [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ripa, E. Jorgensen, Y. Wang, J. J. Thune, J. C. Nilsson, L. Sondergaard, H. E. Johnsen, L. Kober, P. Grande, and J. Kastrup Stem Cell Mobilization Induced by Subcutaneous Granulocyte-Colony Stimulating Factor to Improve Cardiac Regeneration After Acute ST-Elevation Myocardial Infarction: Result of the Double-Blind, Randomized, Placebo-Controlled Stem Cells in Myocardial Infarction (STEMMI) Trial Circulation, April 25, 2006; 113(16): 1983 - 1992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takamiya, M. Okigaki, D. Jin, S. Takai, Y. Nozawa, Y. Adachi, N. Urao, K. Tateishi, T. Nomura, K. Zen, et al. Granulocyte Colony-Stimulating Factor-Mobilized Circulating c-Kit+/Flk-1+ Progenitor Cells Regenerate Endothelium and Inhibit Neointimal Hyperplasia After Vascular Injury Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 751 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zohlnhofer, I. Ott, J. Mehilli, K. Schomig, F. Michalk, T. Ibrahim, G. Meisetschlager, J. von Wedel, H. Bollwein, M. Seyfarth, et al. Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients With Acute Myocardial Infarction: A Randomized Controlled Trial JAMA, March 1, 2006; 295(9): 1003 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. de Muinck and M. Simons Calling on Reserves: Granulocyte Colony Stimulating Growth Factor in Cardiac Repair Circulation, November 15, 2005; 112(20): 3033 - 3035. [Full Text] [PDF]
|
|