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European Heart Journal Advance Access published online on May 23, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi333
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received February 25, 2005
Revised April 18, 2005
Accepted April 22, 2005

Review

Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis

Arnold G. Herman 1* and Salvador Moncada 2

1 Division of Pharmacology, University of Antwerpen, Campus Drie Eiken, Wilrijk, B-2610 Antwerpen, Belgium
2 Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK

* To whom correspondence should be addressed.
Arnold G. Herman, E-mail: arnold.herman{at}ua.ac.be


  Abstract

Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin.

Keywords: Nitric oxide; Atherosclerosis; Nitric oxide donor.
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