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European Heart Journal Advance Access published online on July 8, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi407
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received January 19, 2005
Revised June 13, 2005
Accepted June 16, 2005

Clinical research

Plasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease

Anushka Patel 1*, Mark Woodward 1, Duncan J. Campbell 2, David R. Sullivan 3, Samuel Colman 1, John Chalmers 1, Bruce Neal 1, and Stephen MacMahon 1

1 The George Institute for International Health, University of Sydney, PO Box M201, Missenden Road, Sydney, NSW 2050, Australia
2 St Vincent's Institute of Medical Research, Victoria, Australia; Department of Medicine, University of Melbourne, Victoria, Australia
3 Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia

* To whom correspondence should be addressed.
Anushka Patel, E-mail: apatel{at}thegeorgeinstitute.org


  Abstract

Aims To evaluate the role of plasma lipids in recurrent vascular events, including stroke, among individuals with established cerebrovascular disease.

Methods and results Plasma total cholesterol, HDL cholesterol, and triglycerides were measured at baseline among individuals participating in the Perindopril Protection Against Recurrent Stroke (PROGRESS) study, a randomized clinical trial of blood pressure lowering among patients with previous stroke or transient ischaemic attack. A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk of subsequent haemorrhagic stroke, ischaemic stroke, myocardial infarction (MI), and heart failure. A total of 895 patients were selected as cases (83 haemorrhagic stroke, 472 ischaemic stroke, 206 MI, and 258 heart failure) and each was matched with one to three controls. After adjustment for other major cardiovascular risk factors, none of the lipid variables was associated with the risk of either stroke subtype. There were significant positive and negative associations for total cholesterol and HDL, respectively, with the risk of MI; the odds ratio comparing the highest and lowest thirds of each of these lipid variables was 2.00 (95% CI: 1.30-3.09) for total cholesterol and 0.58 (95% CI: 0.37-0.90) for HDL. HDL was inversely associated with the risk of heart failure; however, this result was of borderline statistical significance (P = 0.05).

Conclusion Lipid variables are associated with the risk of MI, but not recurrent stroke, in patients with established cerebrovascular disease.

Keywords: Nested case-control study; Ischaemic stroke; Haemorrhagic stroke; Myocardial infarction; Heart failure.
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