European Heart Journal Advance Access published online on July 29, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi433
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1 Department of Cardiac and Vascular Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
* To whom correspondence should be addressed. Aims To assess, in chronic stable angina (CSA) patients, the relationship among clinical characteristics and cardiovascular risk factors, extent of coronary artery disease (CAD), and pregnancy-associated plasma protein-A (PAPP-A) levels. Methods and results We studied 643 CSA patients (63 ± 10 years, 482 men) undergoing diagnostic coronary angiography; 97 with angiographically normal coronary arteries or < 50% stenosis, 127 with single vessel disease (VD), and 419 with multi-VD. Patients' age, gender, cardiovascular risk factors, body mass index, history of previous myocardial infarction, angina class, left ventricular ejection fraction (LVEF), and treatment were assessed at study entry. PAPP-A levels (mIU/L) were higher in men than in women (6.2 ± 2.4 vs. 5.2 ± 1.8; P < 0.001) and in hypertensive vs. normotensive patients (6.4 ± 2.8 vs. 5.8 ± 2.1; P = 0.01). PAPP-A correlated directly with age (r = 0.19, P < 0.001) and inversely with LVEF (r = -0.11, P = 0.01). Patients with multivessel disease (VD) had higher PAPP-A levels (6.45 ± 2.58) than those with single-VD (5.49 ± 1.54, P < 0.001) or normal coronaries (4.62 ± 1.17, P < 0.001). Male gender, age, history of a previous MI, hypercholesterolaemia, and PAPP-A levels were independent predictors for the presence of CAD. Conclusion In CSA patients PAPP-A levels correlate with age, male gender, hypertension, and CAD extent. In the present study, PAPP-A was an independent predictor for the presence and extent of CAD.
Received September 21, 2004
Revised June 21, 2005
Accepted June 30, 2005
Clinical research
Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris
2 Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark; Copenhagen Heart Arrhythmia Research Center, Copenhagen, Denmark
3 Department of Molecular Biology, Science Park, University of Aarhus, Aarhus, Denmark
Juan Carlos Kaski, E-mail: jkaski{at}sghms.ac.uk
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