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European Heart Journal Advance Access published online on August 16, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi436
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received May 9, 2005
Revised June 18, 2005
Accepted July 7, 2005

Clinical research

Serum hepatocyte growth factor levels predict long-term clinical outcome after percutaneous coronary revascularization

Sophie Susen 1, Karine Sautière 2, Frédéric Mouquet 2, François Cuilleret 3, Akram Chmaït 3, Eugène P. Mc Fadden 3, Bernadette Hennache 4, Florence Richard 5, Pascal de Groote 3, Jean-Marc Lablanche 3, Jean Dallongeville 5, Christophe Bauters 6, Brigitte Jude 1, and Eric Van Belle 2*

1 Department of Hematology, University Hospital, Lille, France; INSERM-ESPRI 2004-EA 2693, Lille II University, Lille, France
2 Department of Cardiology, University Hospital, Lille, France; INSERM-ESPRI 2004-EA 2693, Lille II University, Lille, France
3 Department of Cardiology, University Hospital, Lille, France
4 Department of Biochemistry, University Hospital, Lille, France
5 INSERM-U508, Institut Pasteur, Lille, France
6 Department of Cardiology, University Hospital, Lille, France; INSERM-U508, Institut Pasteur, Lille, France

* To whom correspondence should be addressed.
Eric Van Belle, E-mail: ericvanbelle{at}aol.com


  Abstract

Aims To evaluate, in patients referred for elective percutaneous coronary revascularization (PCR) without heparin pre-treatment, the relationship between baseline serum levels of the angiogenic growth factors, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), and clinical outcome.

Methods and results In 488 consecutive patients undergoing elective coronary angioplasty, hsC-reactive protein, HGF, and VEGF levels were measured before heparin administration. The primary endpoint, a composite of death and myocardial infarction, occurred in 44 patients at a median follow-up of 14.9 months. At baseline, VEGF levels were related to C-reactive protein levels and inversely related to age; HGF levels were related to C-reactive protein levels, diabetes, and recent clinical instability. In the univariate analysis, HGF had a significant positive relationship (P = 0.003) with the primary endpoint. A similar trend was observed for VEGF (P = 0.11). The only three variables significantly associated with the primary endpoint in the multivariable Cox model were HGF (P = 0.004), C-reactive protein (P = 0.007), and diabetes (P = 0.04).

Conclusion Our results demonstrate that in patients, without heparin pre-treatment, referred for PCR, a high serum level of HGF is an independent predictor of clinical events during follow-up and is correlated with other surrogate measures of the activity of atherosclerosis.

Keywords: Angioplasty; Growth factors; Diabetes mellitus; C-reactive protein; Clinical outcome.
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