Skip Navigation



European Heart Journal Advance Access published online on August 16, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi440
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/22/2435    most recent
ehi440v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Svatikova, A.
Right arrow Articles by Somers, V. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Svatikova, A.
Right arrow Articles by Somers, V. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received March 29, 2005
Revised June 16, 2005
Accepted July 7, 2005

Clinical research

Oxidative stress in obstructive sleep apnoea

Anna Svatikova 1, Robert Wolk 1, Lilach O. Lerman 1, Luis A. Juncos 1, Eddie L. Greene 1, Joseph P. McConnell 1, and Virend K. Somers 1*

1 Mayo Clinic College of Medicine, Rochester, MN 55905, USA

* To whom correspondence should be addressed.
Virend K. Somers, E-mail: somers.virend{at}mayo.edu


  Abstract

Aims Any sustained elevation of oxidative stress in patients with obstructive sleep apnoea (OSA) might help explain their increased risk for cardiovascular diseases. We tested the hypothesis that measures of oxidative stress are increased in otherwise healthy subjects with OSA when compared to closely matched OSA-free control subjects.

Methods and results Plasma indices of oxidative stress and lipid peroxidation [thiobarbituric acid-reactive substances (TBARS), oxidized LDL (oxLDL), isoprostanes] were measured in 41 moderate-severe OSA males without other diseases and in 35 matched controls first before sleep, then after 4 h of untreated OSA, and again in the morning after 4 h of effective treatment with continuous positive airway pressure (CPAP). Plasma levels of oxLDL, TBARS, and isoprostanes in OSA patients (n = 34, 26, 17, respectively) were comparable to the controls (n = 28, 27, 15 for the three markers, respectively). Neither untreated OSA nor CPAP treatment nor normal sleep affected levels of any of the three measures of oxidative stress. There was no association between the severity of sleep apnoea and any measure of oxidative stress.

Conclusion Otherwise healthy OSA patients, without any other co-morbidities, do not manifest evidence for higher oxidative stress and lipid peroxidation. Thus, oxidative stress and lipid peroxidation do not appear to be key mediators of increased cardiovascular disease in OSA patients.

Keywords: Oxidative stress; oxLDL; TBARS; Isoprostanes; Obstructive sleep apnoea; Cardiovascular diseases.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Circulation, September 2, 2008; 118(10): 1080 - 1111.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 686 - 717.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Lefebvre, J-L. Pepin, J-P. Baguet, R. Tamisier, M. Roustit, K. Riedweg, G. Bessard, P. Levy, and F. Stanke-Labesque
Leukotriene B4: early mediator of atherosclerosis in obstructive sleep apnoea?
Eur. Respir. J., July 1, 2008; 32(1): 113 - 120.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M D Cross, N L Mills, M Al-Abri, R Riha, M Vennelle, T W Mackay, D E Newby, and N J Douglas
Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial
Thorax, July 1, 2008; 63(7): 578 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Faure, R. Tamisier, J-P. Baguet, A. Favier, S. Halimi, P. Levy, and J-L. Pepin
Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome
Eur. Respir. J., May 1, 2008; 31(5): 1046 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Lopez-Jimenez, F. H. Sert Kuniyoshi, A. Gami, and V. K. Somers
Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease
Chest, March 1, 2008; 133(3): 793 - 804.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. H. Sanders, J. M. Montserrat, R. Farre, and R. J. Givelber
Positive Pressure Therapy: A Perspective on Evidence-based Outcomes and Methods of Application
Proceedings of the ATS, February 15, 2008; 5(2): 161 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
R. Wolk and V. K. Somers
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Sleep and the metabolic syndrome
Exp Physiol, January 1, 2007; 92(1): 67 - 78.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. L. Phillips and R. R. Grunstein
Obstructive sleep apnoea: time for a radical change?
Eur. Respir. J., April 1, 2006; 27(4): 671 - 673.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.