Skip Navigation



European Heart Journal Advance Access published online on September 1, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi483
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
26/23/2556    most recent
ehi483v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Osranek, M.
Right arrow Articles by Seward, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Osranek, M.
Right arrow Articles by Seward, J. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received May 24, 2005
Revised July 12, 2005
Accepted August 11, 2005

Clinical research

Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up

Martin Osranek 1, Francesca Bursi 1, Kent R. Bailey 2, Brandon R. Grossardt 2, Robert D. Brown Jr3, Stephen L. Kopecky 1, Teresa S. Tsang 1, and James B. Seward 1*

1 Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
2 Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
3 Department of Neurology, Mayo Clinic, Rochester, MN, USA

* To whom correspondence should be addressed.
James B. Seward, E-mail: seward{at}mayo.edu


  Abstract

Aims The objectives of this study were to determine the long-term outcome and the predictors of adverse events in patients originally diagnosed with lone atrial fibrillation (AF).

Methods and results This population-based historical cohort study comprised 46 residents of Olmsted County, MN, USA, with well-documented, clinically defined lone AF and a complete two-dimensional echocardiographic examination. The original echocardiographic videotape recordings were analysed in a blinded fashion for left atrial volume (LAV) and left ventricular ejection fraction. With 1296 person-years of follow-up, the median duration of AF was 27 (first quartile = 24, third quartile = 33) years. Twenty-three (50%) patients developed events. Cerebral infarction occurred in seven patients, myocardial infarction in 11, and congestive heart failure in 16. In a multivariable analysis, patients with indexed LAV ≥32 mL/m2 had a significantly worse event-free survival (adjusted HR, 4.46; 95% CI, 1.56-12.74; P = 0.005). All cerebral infarctions occurred in patients with an indexed LAV >32 mL/m2.

Conclusion Patients originally diagnosed with benign lone AF follow divergent courses based on LAV. Those originally diagnosed with lone AF and normal sized atria had a benign clinical course throughout the long-term follow-up. Patients with increased LAV at diagnosis or later during the follow-up experienced adverse events.

Keywords: Lone atrial fibrillation; Left atrial volume; Echocardiography; Cerebral infarction.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
F. Belluzzi, L. Sernesi, P. Preti, F. Salinaro, M. L. Fonte, and S. Perlini
Prevention of recurrent lone atrial fibrillation by the angiotensin-II converting enzyme inhibitor ramipril in normotensive patients.
J. Am. Coll. Cardiol., January 6, 2009; 53(1): 24 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
K. Fatema, K. R. Bailey, G. W. Petty, I. Meissner, M. Osranek, A. A. Alsaileek, B. K. Khandheria, T. S. Tsang, and J. B. Seward
Increased Left Atrial Volume Index: Potent Biomarker for First-Ever Ischemic Stroke
Mayo Clin. Proc., October 1, 2008; 83(10): 1107 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
B. A. Schoonderwoerd, M. D. Smit, L. Pen, and I. C. Van Gelder
New risk factors for atrial fibrillation: causes of 'not-so-lone atrial fibrillation'
Europace, June 1, 2008; 10(6): 668 - 673.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
L. F Tops, E. E van der Wall, M. J Schalij, and J. J Bax
Multi-modality imaging to assess left atrial size, anatomy and function
Heart, November 1, 2007; 93(11): 1461 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. Messika-Zeitoun, M. Bellamy, J.-F. Avierinos, J. Breen, C. Eusemann, A. Rossi, T. Behrenbeck, C. Scott, J. A. Tajik, and M. Enriquez-Sarano
Left atrial remodelling in mitral regurgitation--methodologic approach, physiological determinants, and outcome implications: a prospective quantitative Doppler-echocardiographic and electron beam-computed tomographic study
Eur. Heart J., July 2, 2007; 28(14): 1773 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Struthers and C. Lang
The potential to improve primary prevention in the future by using BNP/N-BNP as an indicator of silent 'pancardiac' target organ damage: BNP/N-BNP could become for the heart what microalbuminuria is for the kidney
Eur. Heart J., July 2, 2007; 28(14): 1678 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Frost
Lone Atrial Fibrillation: Good, Bad, or Ugly?
Circulation, June 19, 2007; 115(24): 3040 - 3041.
[Full Text] [PDF]

Home page
 CirculationHome page
A. Jahangir, V. Lee, P. A. Friedman, J. M. Trusty, D. O. Hodge, S. L. Kopecky, D. L. Packer, S. C. Hammill, W.-K. Shen, and B. J. Gersh
Long-Term Progression and Outcomes With Aging in Patients With Lone Atrial Fibrillation: A 30-Year Follow-Up Study
Circulation, June 19, 2007; 115(24): 3050 - 3056.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Berruezo, D. Tamborero, L. Mont, B. Benito, J. M. Tolosana, M. Sitges, B. Vidal, G. Arriagada, F. Mendez, M. Matiello, et al.
Pre-procedural predictors of atrial fibrillation recurrence after circumferential pulmonary vein ablation
Eur. Heart J., April 1, 2007; 28(7): 836 - 841.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. J. Manning and E. V. Gelfand
Left Atrial Size and Postoperative Atrial Fibrillation: The Volume of Evidence Suggests it Is Time to Break an Old Habit
J. Am. Coll. Cardiol., August 15, 2006; 48(4): 787 - 789.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Osranek, K. Fatema, F. Qaddoura, A. Al-Saileek, M. E. Barnes, K. R. Bailey, B. J. Gersh, T. S.M. Tsang, K. J. Zehr, and J. B. Seward
Left Atrial Volume Predicts the Risk of Atrial Fibrillation After Cardiac Surgery: A Prospective Study
J. Am. Coll. Cardiol., August 15, 2006; 48(4): 779 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Evid. Based Med.Home page
Other articles noted
Evid. Based Med., June 1, 2006; 11(3): 95 - 96.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Rienstra and I. C. Van Gelder
Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up
Eur. Heart J., March 2, 2006; 27(6): 756 - 756.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Osranek and J. B. Seward
Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up: reply
Eur. Heart J., March 2, 2006; 27(6): 756 - 756.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Bollmann
First comes diagnosis then comes treatment: an underappreciated paradigm in atrial fibrillation management
Eur. Heart J., December 1, 2005; 26(23): 2487 - 2489.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.