Skip Navigation



European Heart Journal Advance Access published online on September 23, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi506
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/1/96    most recent
ehi506v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Murphy, N.F.
Right arrow Articles by McMurray, J.J.V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, N.F.
Right arrow Articles by McMurray, J.J.V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received May 11, 2005
Revised August 26, 2005
Accepted September 2, 2005

Clinical research

Long-term cardiovascular consequences of obesity: 20-year follow-up of more than 15 000 middle-aged men and women (the Renfrew-Paisley study)

N.F. Murphy 1, K. MacIntyre 2, S. Stewart 3, C.L. Hart 2, D. Hole 2, and J.J.V. McMurray 1*

1 Department of Cardiology, Western Infirmary, Glasgow G12 8QQ, UK
2 Public Health and Health Policy, University of Glasgow, Scotland, UK
3 Division of Health Sciences, University of South Australia, Adelaide, Australia

* To whom correspondence should be addressed.
J.J.V. McMurray, E-mail: j.mcmurray{at}bio.gla.ac.uk


  Abstract

Aims To examine the long-term cardiovascular consequences of obesity and project the cardiovascular consequences of the recent increase in prevalence of obesity.

Methods and results Between 1972 and 1976, 15 402 individuals aged 45-64, living in two towns in the west of Scotland underwent comprehensive cardiovascular screening. We analysed all deaths and hospitalizations for cardiovascular reasons occurring over the subsequent 20 years according to baseline body mass index (BMI) category. Compared with normal weight individuals (BMI 18.5-24.9), obesity (BMI ≥ 30) was associated with an increased adjusted risk of coronary heart disease (hazard ratio for death or hospital admission: 1.60, 95% CI 1.45-1.78), heart failure (2.09, 1.68-2.59), stroke (1.41, 1.21-1.65), venous thrombo-embolism (2.29, 1.60-3.30), and atrial fibrillation (1.75, 1.17-2.65). Obesity was associated with nine additional cardiovascular deaths and 36 additional cardiovascular hospital admissions for every 100 affected middle-aged men over the subsequent 20 years (seven deaths and 28 admissions in women). Assuming no change in cardiovascular risk profile and outcomes related to obesity, the increase in prevalence in 1998, when compared with 1972, is projected to lead to an additional four cardiovascular deaths and 14 admissions per 100 middle-aged men and women over the next 20 years.

Conclusion Obesity is associated with an increase in a broad range of fatal and non-fatal cardiovascular events. Consideration of only coronary, only fatal, and only first events greatly underestimates the cardiovascular consequences of obesity.

Keywords: Obesity; Coronary heart disease; Heart failure; Atrial fibrillation; Stroke; Thromboembolism.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
N. Chopin, J. M. Malaret, M.-C. Lafay-Pillet, A. Fotso, H. Foulot, and C. Chapron
Total laparoscopic hysterectomy for benign uterine pathologies: obesity does not increase the risk of complications
Hum. Reprod., October 3, 2009; (2009) dep348v1.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Poirier, M. A. Alpert, L. A. Fleisher, P. D. Thompson, H. J. Sugerman, L. E. Burke, P. Marceau, B. A. Franklin, and on behalf of the American Heart Association Obesit
Cardiovascular Evaluation and Management of Severely Obese Patients Undergoing Surgery: A Science Advisory From the American Heart Association
Circulation, July 7, 2009; 120(1): 86 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Occup. Environ. Med.Home page
H Claessen, V Arndt, C Drath, and H Brenner
Overweight, obesity and risk of work disability: a cohort study of construction workers in Germany
Occup. Environ. Med., June 1, 2009; 66(6): 402 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Circ Heart FailHome page
E. B. Levitan, A. Z. Yang, A. Wolk, and M. A. Mittleman
Adiposity and Incidence of Heart Failure Hospitalization and Mortality: A Population-Based Prospective Study
Circ Heart Fail, May 1, 2009; 2(3): 202 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
N. C. Cavarocchi
Invited commentary.
Ann. Thorac. Surg., February 1, 2009; 87(2): 546 - 547.
[Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
J. McMurray, M. Petrie, K. Swedberg, M. Komajda, S. Anker, and R. Gardner
CHAPTER 23 Heart Failure
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Ashrafian, C. W. le Roux, A. Darzi, and T. Athanasiou
Effects of Bariatric Surgery on Cardiovascular Function
Circulation, November 11, 2008; 118(20): 2091 - 2102.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. C. Kaplan, G. Y.F. Ho, X. Xue, S. Rajpathak, M. Cushman, T. E. Rohan, H. D. Strickler, P. E. Scherer, and K. Anastos
Within-Individual Stability of Obesity-Related Biomarkers among Women
Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1291 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 J Public Health (Oxf)Home page
C. L. Hart, D. J. Hole, D. A. Lawlor, and G. D. Smith
Obesity and use of acute hospital services in participants of the Renfrew/Paisley study
J. Public Health Med., March 1, 2007; 29(1): 53 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
A. Bayes-Genis, D. M. Lloyd-Jones, R. R. J. van Kimmenade, J. G. Lainchbury, A. M. Richards, J. Ordonez-Llanos, M. Santalo, Y. M. Pinto, and J. L. Januzzi Jr
Effect of Body Mass Index on Diagnostic and Prognostic Usefulness of Amino-Terminal Pro-Brain Natriuretic Peptide in Patients With Acute Dyspnea
Arch Intern Med, February 26, 2007; 167(4): 400 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. J. L. Bakker, R. T. Gansevoort, and D. de Zeeuw
Metabolic syndrome: a fata morgana?
Nephrol. Dial. Transplant., January 1, 2007; 22(1): 15 - 20.
[Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Barter
Options for therapeutic intervention: how effective are the different agents?
Eur. Heart J. Suppl., October 1, 2006; 8(suppl_F): F47 - F53.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
A. Elhendy, A. F.L. Schinkel, R. T. van Domburg, J. J. Bax, R. Valkema, E. Biagini, and D. Poldermans
Prognostic Stratification of Obese Patients by Stress 99mTc-Tetrofosmin Myocardial Perfusion Imaging
J. Nucl. Med., August 1, 2006; 47(8): 1302 - 1306.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.