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European Heart Journal Advance Access published online on October 11, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi605
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European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received May 30, 2005
Revised September 21, 2005
Accepted September 29, 2005

Review

Diet and inflammation: a link to metabolic and cardiovascular diseases

Katherine Esposito 1 and Dario Giugliano 1*

1 Division of Metabolic Diseases, Policlinico Seconda Università di Napoli, University of Naples, Piazza L. Miraglia, 80138 Naples, Italy

* To whom correspondence should be addressed.
Dario Giugliano, E-mail: dario.giugliano{at}unina2.it


  Abstract

Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through which unhealthy diets are linked to metabolic and cardiovascular diseases. In practical terms, fully understanding the link between diet and inflammation holds the premise to elucidate the mechanisms by which dietary patterns improve cardiovascular health.

Keywords: Dietary patterns; Inflammation; Endothelial dysfunction; Insulin resistance; Metabolic syndrome.
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