Skip Navigation



European Heart Journal Advance Access published online on November 2, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi628
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/3/283    most recent
ehi628v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wojakowski, W.
Right arrow Articles by Ratajczak, M. Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wojakowski, W.
Right arrow Articles by Ratajczak, M. Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received February 28, 2005
Revised October 6, 2005
Accepted October 13, 2005

Clinical research

Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction

Wojciech Wojakowski 1*, Michal Tendera 1, Anna Zebzda 2, Anna Michalowska 2, Marcin Majka 2, Magdalena Kucia 3, Katarzyna Maslankiewicz 1, Rafal Wyderka 1, Marek Król 1, Andrzej Ochala 1, Krystyna Kozakiewicz 1, and Mariusz Z. Ratajczak 4

1 3rd Division of Cardiology, Silesian School of Medicine, 45-47 Ziolowa Street, 40-635 Katowice, Poland
2 Department of Transplantology, Polish-American Children's Hospital, Medical College, Jagiellonian University, 265 Wielicka Street, 30-663 Kraków, Poland
3 Stem Cell Biology Program at James Graham Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY 40202, USA
4 Department of Transplantology, Polish-American Children's Hospital, Medical College, Jagiellonian University, 265 Wielicka Street, 30-663 Kraków, Poland; Stem Cell Biology Program at James Graham Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY 40202, USA

* To whom correspondence should be addressed.
Wojciech Wojakowski, E-mail: wojwoj{at}mp.pl


  Abstract

Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI).

Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (<12 h) in AMI was significantly, positively correlated with LVEF: r = 0.49 (P = 0.0012) for CD34+ cells, r = 0.48 (P = 0.0018) for CXCR4+ cells, r = 0.45 (P = 0.0043) for CD117+ cells, and r = 0.41 (P = 0.01) for c-met+ cells and negatively correlated with NT-proBNP levels on admission r = -0.35 (P = 0.024) for CD34+ cells, r = -0.42 (P = 0.007) for CXCR4+ cells, r = -0.33 (P = 0.04). In patients with LVEF ≤40%, the peak number of CD34+, CXCR4+, CD117+, and c-met+ stem cells was significantly lower when compared patients with LVEF >40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r = -0.37; P = 0.029 and r = -0.45, P = 0.02) and maximum activity of CK-MB (r = -0.37; P = 0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found.

Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.

Keywords: Blood cells; Myocardial infarction; Inflammation; Left ventricular ejection fraction; Natriuretic peptides.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
M. Tendera, W. Wojakowski, W. Ruzyllo, L. Chojnowska, C. Kepka, W. Tracz, P. Musialek, W. Piwowarska, J. Nessler, P. Buszman, et al.
Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial
Eur. Heart J., June 1, 2009; 30(11): 1313 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. M. Leone, M. Valgimigli, M. B. Giannico, V. Zaccone, M. Perfetti, D. D'Amario, A. G. Rebuzzi, and F. Crea
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells
Eur. Heart J., April 2, 2009; 30(8): 890 - 899.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. Wojakowski, M. Tendera, M. Kucia, E. Zuba-Surma, E. Paczkowska, J. Ciosek, M. Halasa, M. Krol, M. Kazmierski, P. Buszman, et al.
Mobilization of bone marrow-derived Oct-4+ SSEA-4+ very small embryonic-like stem cells in patients with acute myocardial infarction.
J. Am. Coll. Cardiol., January 6, 2009; 53(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
M. Valgimigli, G. G.L. Biondi-Zoccai, P. Malagutti, A. M. Leone, and A. Abbate
Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after myocardial infarction
Eur. Heart J. Suppl., December 1, 2008; 10(suppl_K): K27 - K34.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
W. Wojakowski, M. Kucia, K. Milewski, B. Machalinski, M. Halasa, P. Buszman, P. Klimeczek, M. Kazmierski, M. Pasowicz, M. Z. Ratajczak, et al.
The role of CXCR4/SDF-1, CD117/SCF, and c-met/HGF chemokine signalling in the mobilization of progenitor cells and the parameters of the left ventricular function, remodelling, and myocardial perfusion following acute myocardial infarction
Eur. Heart J. Suppl., December 1, 2008; 10(suppl_K): K16 - K23.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Martin-Rendon, S. J. Brunskill, C. J. Hyde, S. J. Stanworth, A. Mathur, and S. M. Watt
Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review
Eur. Heart J., August 1, 2008; 29(15): 1807 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
W Wojakowski, M Kucia, M Kazmierski, M Z Ratajczak, and M Tendera
Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism?
Heart, January 1, 2008; 94(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. M. Leone and F. Crea
Stem cells in acute myocardial infarction: the good, the bad, and the ugly
Eur. Heart J., December 2, 2006; 27(24): 2911 - 2913.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. J. Post and J. Waltenberger
ACE inhibitors and statins for bone marrow failure following myocardial infarction?
Cardiovasc Res, April 1, 2006; 70(1): 1 - 2.
[Full Text] [PDF]

Home page
 JAMAHome page
D. Zohlnhofer, I. Ott, J. Mehilli, K. Schomig, F. Michalk, T. Ibrahim, G. Meisetschlager, J. von Wedel, H. Bollwein, M. Seyfarth, et al.
Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients With Acute Myocardial Infarction: A Randomized Controlled Trial
JAMA, March 1, 2006; 295(9): 1003 - 1010.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.