Skip Navigation



European Heart Journal Advance Access published online on November 30, 2005
European Heart Journal, doi:10.1093/eurheartj/ehi666
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/4/460    most recent
ehi666v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jacobs, L. D.
Right arrow Articles by Lang, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacobs, L. D.
Right arrow Articles by Lang, R. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2005; all rights reserved
Received July 20, 2005
Revised October 24, 2005
Accepted November 3, 2005

Clinical research

Rapid online quantification of left ventricular volume from real-time three-dimensional echocardiographic data

Lawrence D. Jacobs 1, Ivan S. Salgo 2, Sascha Goonewardena 1, Lynn Weinert 1, Patrick Coon 1, Dianna Bardo 3, Olivier Gerard 4, Pascal Allain 4, Jose L. Zamorano 5, Leopoldo P. de Isla 5, Victor Mor-Avi 1, and Roberto M. Lang 1 *

1 Noninvasive Cardiac Imaging Laboratory, University of Chicago Hospitals, 5841 S. Maryland Avenue, MC 5084, Chicago, IL 60637, USA
2 Philips Medical Systems, Andover, MA, USA
3 Department of Radiology, University of Chicago, Chicago, IL, USA
4 Philips Medical Systems, Paris, France
5 University Clinic San Carlos, Madrid, Spain

* To whom correspondence should be addressed.
Roberto M. Lang, E-mail: rlang{at}medicine.bsd.uchicago.edu


  Abstract

Aims Determination of left ventricular (LV) volumes and ejection fraction (EF) from two-dimensional echocardiographic (2DE) images is subjective, time-consuming, and relatively inaccurate because of foreshortened views and the use of geometric assumptions. Our aims were (1) to validate a new method for rapid, online measurement of LV volumes from real-time three-dimensional echocardiographic (RT3DE) data using cardiac magnetic resonance (CMR) as the reference and (2) to compare its accuracy and reproducibility with standard 2DE measurements.

Methods and results CMR, 2DE, and RT3DE datasets were obtained in 50 patients. End-systolic and end-diastolic volumes (ESV and EDV) were calculated from the 2DE images using biplane method of disks. ES and ED RT3DE datasets were analysed using prototype software designed to automatically detect the endocardial surface using a deformable shell model and calculate ESV and EDV from voxel counts. 2DE and RT3DE-derived volumes were compared with CMR (linear regression, Bland-Altman analysis). In most patients, analysis of RT3DE data required < 2 min per patient. RT3DE measurements correlated highly with CMR (r: 0.96, 0.97, and 0.93 for EDV, ESV, and EF, respectively) with small biases (-14 mL, - 6.5 mL, - 1%) and narrow limits of agreement (SD: 17 mL, 16 mL, 6.4%). 2DE measurements correlated less well with CMR (r: 0.89, 0.92, 0.86) with greater biases (-23 mL, - 15 mL, 1%) and wider limits of agreement (SD: 29 mL, 24 mL, 9.5%). RT3DE resulted in lower intra-observer (EDV: 7.9 vs. 23%; ESV: 7.6 vs. 26%) and inter-observer variability (EDV: 11 vs. 26%; ESV: 13 vs. 31%).

Conclusion Semi-automated detection of the LV endocardial surface from RT3DE data is suitable for clinical use because it allows rapid, accurate, and reproducible measurements of LV volumes, superior to conventional 2DE methods.

Keywords: Echocardiography; Magnetic resonance; Ventricular function; Ejection fraction.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
W.-J. Flu, J.-P. van Kuijk, J. J. Bax, J. Gorcsan III, and D. Poldermans
Three-dimensional speckle tracking echocardiography: a novel approach in the assessment of left ventricular volume and function?
Eur. Heart J., October 1, 2009; 30(19): 2304 - 2307.
[Full Text] [PDF]

Home page
 J Ultrasound MedHome page
M. Ren, J.-W. Tian, X.-P. Leng, H.-M. Wang, Y. Wang, and Z.-Z. Wang
Assessment of Global and Regional Left Ventricular Function After Surgical Revascularization in Patients With Coronary Artery Disease by Real-time Triplane Echocardiography
J. Ultrasound Med., September 1, 2009; 28(9): 1175 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
H.-J. Nesser, V. Mor-Avi, W. Gorissen, L. Weinert, R. Steringer-Mascherbauer, J. Niel, L. Sugeng, and R. M. Lang
Quantification of left ventricular volumes using three-dimensional echocardiographic speckle tracking: comparison with MRI
Eur. Heart J., July 1, 2009; 30(13): 1565 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
V. Delgado, J. J. Bax, and E. E. van der Wall
Towards assessment of left ventricular mechanics in true three dimensions
Eur. Heart J., July 1, 2009; 30(13): 1554 - 1555.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
P. Ballo, A. Motto, S. Mondillo, and M. Galderisi
Three-dimensional echocardiography for optimization of cardiac resynchronization therapy
Eur. Heart J., February 2, 2009; 30(4): 505 - 505.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
T. Stanton, N. M. Hawkins, K. J. Hogg, N. E.R. Goodfield, M. C. Petrie, and J. J.V. McMurray
Three-dimensional echocardiography for optimization of cardiac resynchronization therapy: reply
Eur. Heart J., February 2, 2009; 30(4): 505 - 506.
[Full Text] [PDF]

Home page
 CirculationHome page
V. Mor-Avi, L. Sugeng, and R. M. Lang
Real-Time 3-Dimensional Echocardiography: An Integral Component of the Routine Echocardiographic Examination in Adult Patients?
Circulation, January 20, 2009; 119(2): 314 - 329.
[Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
T. Nishikage, H. Nakai, V. Mor-Avi, R. M. Lang, I. S. Salgo, S. H. Settlemier, S. Husson, and M. Takeuchi
Quantitative assessment of left ventricular volume and ejection fraction using two-dimensional speckle tracking echocardiography
Eur J Echocardiogr, January 1, 2009; 10(1): 82 - 88.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
L. Sugeng, V. Mor-Avi, and R. M Lang
Three-dimensional echocardiography: coming of age
Heart, September 1, 2008; 94(9): 1123 - 1125.
[Full Text] [PDF]

Home page
 HeartHome page
A-C Pouleur, J-B le Polain de Waroux, A Pasquet, B L Gerber, O Gerard, P Allain, and J-L J Vanoverschelde
Assessment of left ventricular mass and volumes by three-dimensional echocardiography in patients with or without wall motion abnormalities: comparison against cine magnetic resonance imaging
Heart, August 1, 2008; 94(8): 1050 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. L. Gutierrez-Chico, J. L. Zamorano, E. Prieto-Moriche, R. A. Hernandez-Antolin, M. Bravo-Amaro, L. Perez de Isla, M. Sanmartin-Fernandez, J. A. Baz-Alonso, and A. Iniguez-Romo
Real-time three-dimensional echocardiography in aortic stenosis: a novel, simple, and reliable method to improve accuracy in area calculation
Eur. Heart J., May 2, 2008; 29(10): 1296 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
C. Jenkins, M. Monaghan, G. Shirali, R. Guraraja, and T. H. Marwick
An intensive interactive course for 3D echocardiography: is 'crop till you drop' an effective learning strategy?
Eur J Echocardiogr, May 1, 2008; 9(3): 373 - 380.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J L Hare, C Jenkins, S Nakatani, A Ogawa, C-M Yu, and T H Marwick
Feasibility and clinical decision-making with 3D echocardiography in routine practice
Heart, April 1, 2008; 94(4): 440 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. N. Kirkpatrick, M. A. Vannan, J. Narula, and R. M. Lang
Echocardiography in Heart Failure: Applications, Utility, and New Horizons
J. Am. Coll. Cardiol., July 31, 2007; 50(5): 381 - 396.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Jenkins, J. Chan, K. Bricknell, M. Strudwick, and T. H. Marwick
Reproducibility of Right Ventricular Volumes and Ejection Fraction Using Real-time Three-Dimensional Echocardiography: Comparison With Cardiac MRI
Chest, June 1, 2007; 131(6): 1844 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. M. Lang, V. Mor-Avi, L. Sugeng, P. S. Nieman, and D. J. Sahn
Three-Dimensional Echocardiography: The Benefits of the Additional Dimension
J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2053 - 2069.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.