European Heart Journal Advance Access published online on January 9, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi717
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 INSERM U508, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France
* To whom correspondence should be addressed. Aims The goal of this study is to assess the association between the metabolic syndrome (MS) and parental history of cardiovascular disease (CVD). Methods and results Participants were recruited in a population survey of 3441 men and women, aged 35-64. MS was defined with NCEP-III guidelines. Familial history of myocardial infarction (MI), angina, and stroke was assessed with a standardized questionnaire. Parental premature CVD was defined if CVD occurred before 55/65 years in the father/mother. A total of 390 men and 281 women had MS. Positive parental CVD was associated with MS in women (43.0 vs. 36.8%, P < 0.001) but not in men (36.9 vs. 31.8%, P = 0.06). Similarly, parental premature CVD was associated with MS in women (19.2 vs. 11.8%, P < 0.0007) but not in men (11.1 vs. 11.1%, ns). In women with MS, the age, centre, and educational level adjusted odds ratios [OR (95% CI)] of having a positive parental premature stroke was 1.84 (1.0-3.38), P = 0.049. This OR was 1.76 (1.23-2.76), P = 0.007 for combined parental premature MI and stroke and 1.67 (1.17-2.38), P = 0.004 for combined premature MI, stroke, and angina. After further adjustment on personal coronary heart disease and CVD risk factors, the ORs of having a positive parental history of combined premature MI and stroke [1.75 (1.11-2.76), P = 0.016] or MI, stroke, and angina [1.79 (1.21-2.63), P = 0.003], remained statistically significant, in women with MS. Conclusion The MS is associated with parental premature CVD independently of classical CV risk factors, suggesting that MS is a contributor to the familial aggregation of premature CVD.
Received May 13, 2005
Revised October 13, 2005
Accepted December 15, 2005
Clinical research
Association between the metabolic syndrome and parental history of premature cardiovascular disease
Jean Dallongeville 1 *,
Marie-Catherine Grupposo 1,
Dominique Cottel 1,
Jean Ferrières 2,
Dominique Arveiler 3,
Annie Bingham 4,
Jean-Bernard Ruidavets 2,
Bernadette Haas 3,
Pierre Ducimetière 4,
and
Philippe Amouyel 5
2 INSERM U558, Faculté de Médecine Purpan, Toulouse, France
3 Laboratoire d'Epidémiologie et de Santé Publique, Strasbourg, France
4 INSERM U258, Hôpital Paul Brousse, Villejuif, France
5 INSERM U508, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France; Faculté de Médecine, Université Lille II, Lille, France
Jean Dallongeville, E-mail: jean.dallongeville{at}pasteur-lille.fr
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Banerjee, L. E. Silver, C. Heneghan, S. J.V. Welch, L. M. Bull, Z. Mehta, A. P. Banning, and P. M. Rothwell Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes Circ Cardiovasc Genet, April 1, 2009; 2(2): 98 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Guize, F. Thomas, B. Pannier, K. Bean, B. Jego, and A. Benetos All-Cause Mortality Associated With Specific Combinations of the Metabolic Syndrome According to Recent Definitions Diabetes Care, September 1, 2007; 30(9): 2381 - 2387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rumboldt, Z. Rumboldt, and S. Pesenti Association between the metabolic syndrome and parental history of premature cardiovascular disease Eur. Heart J., October 2, 2006; 27(20): 2481 - 2481. [Full Text] [PDF]
|
|