European Heart Journal Advance Access published online on January 23, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi732
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1 Department of Cardiology, University of Duisburg-Essen, Hufelandstra
* To whom correspondence should be addressed. Aims To evaluate the pre-clinical feasibility of real-time magnetic resonance imaging (rtMRI) to guide stent-graft placement for experimental aortic dissection (AD) and to alleviate disadvantages of ionising radiation and nephrotoxic contrast media. Endovascular stent-graft placement for thoracic aortic disease is usually performed under X-ray guidance. The feasibility of rtMRI-guided stent-graft placement is currently not known. Methods and results By using a catheter-based technique, dissections of the descending thoracic aorta were successfully created in eight domestic pigs. Subsequent implantation of commercially available, nitinol-based stent-grafts was performed entirely under rtMRI guidance. By pre-interventional MRI, the mean minimal true-lumen diameter was 0.9 (0.825-0.975) cm. rtMRI permitted not only the successful and safe device navigation within the true lumen from the iliac arteries to the thoracic aorta, but also the precise positioning and deployment of the stent-graft and safe withdrawal of the delivery catheter in seven of eight pigs. This was achieved without any other complications. After the stent-graft placement, MRI demonstrated complete obliteration of the false lumen, which was confirmed at autopsy. All stent-grafts were well expanded resulting in an increase in the size of the true-lumen diameter to 2.05 (1.925-2.1) cm (P = 0.066 vs. baseline). Conclusion In experimental AD, rtMRI-guided endovascular stent-graft placement is feasible and safe and has the potential for mitigating radiation and contrast-related side effects. Additionally, it allows not only pre-interventional diagnosis and detailed anatomic diagnosis, but also permits immediate post-interventional, anatomical, and functional delineation of procedure success that may serve as a baseline for future comparison during follow-up.
Received October 17, 2005
Revised December 20, 2005
Accepted December 22, 2005
Preclinical research
Feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissection
Holger Eggebrecht 1 *,
Hilmar Kühl 2,
Gernot M. Kaiser 3,
Stephanie Aker 4,
Michael O. Zenge 2,
Frank Stock 2,
Frank Breuckmann 5,
Florian Grabellus 6,
Mark E. Ladd 2,
Rajendra H. Mehta 7,
Raimund Erbel 5,
and
Harald H. Quick 2
e 55, 45122 Essen, Germany; Department of Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, Germany
2 Department of Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, Germany
3 Department of General and Transplantation Surgery, University of Duisburg-Essen, Essen, Germany
4 Institute of Pathophysiology, University of Duisburg-Essen, Essen, Germany
5 Department of Cardiology, University of Duisburg-Essen, Hufelandstrae 55, 45122 Essen, Germany
6 Institute of Pathology, University of Duisburg-Essen, Essen, Germany
7 Duke Clinical Research Institute, Durham, NC, USA
Holger Eggebrecht, E-mail: holger.eggebrecht{at}uni-essen.de
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