European Heart Journal Advance Access published online on January 18, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi737
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1 Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Tervuursevest 101, 3000 Leuven, Belgium
* To whom correspondence should be addressed. Aims The heritability of aerobic power and of the response to physical training has been shown in healthy subjects. Methods and results Nine hundred and thirty-five biologically unrelated Caucasian patients with CAD who had exercised until exhaustion during graded bicycle testing at baseline and after completion of 3 months of exercise training from 1990 to 2001 (n = 1095) were eligible for inclusion in the CAREGENE (CArdiac REhabilitation and GENetics of Exercise performance) study. Polymorphisms were detected using the invader assay (Third Wave TechnologiesTM, Madison, Wisconsin, USA). Patients with the Gly49Gly genotype had significantly higher covariate-adjusted aerobic power at baseline than those with Ser49Ser and Ser49Gly (P < 0.05). Adjusted aerobic power at baseline was highest in the Ser49-Gly389/Gly49-Gly389 and Gly49-Arg389/Gly49-Arg389 haplotype combinations. Aerobic power increased significantly (P < 0.001) with physical training. There was no association with the effect of physical training. Conclusion Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the
Received September 16, 2005
Revised December 11, 2005
Accepted December 23, 2005
Clinical research
The CAREGENE study: polymorphisms of the
Johan Defoor 1,
Kevin Martens 2,
Dominika Zieli
1-adrenoceptor gene and aerobic power in coronary artery disease
ska 3,
Gert Matthijs 2,
Hilde Van Nerum 1,
Dirk Schepers 1,
Robert Fagard 4,
and
Luc Vanhees 5 *
2 Department of Human Genetics, Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium
3 Department of Rehabilitation, Medical University of Gdansk, Gdansk, Poland
4 Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, K.U. Leuven, Leuven, Belgium
5 Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Tervuursevest 101, 3000 Leuven, Belgium; Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, K.U. Leuven, Leuven, Belgium
Luc Vanhees, E-mail: luc.vanhees{at}faber.kuleuven.be
Abstract 
1-Adrenergic receptor (1AR) function affects exercise performance. This study aims to investigate whether the Ser49Gly and Gly389Arg polymorphisms of the 1AR gene or their haplotypes are associated with aerobic power or its response to physical training in coronary artery disease (CAD).1AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.-Adrenergic receptor; Cardiac rehabilitation; Exercise; Genetics; Oxygen uptake; Polymorphism.
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