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European Heart Journal Advance Access published online on February 7, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi772
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received April 12, 2005
Revised December 21, 2005
Accepted January 19, 2006

Clinical research

Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure

Satoshi Watanabe 1, Junya Shite 1 *, Hideyuki Takaoka 1, Toshiro Shinke 1, Yusuke Imuro 1, Toru Ozawa 1, Hiromasa Otake 1, Daisuke Matsumoto 1, Daisuke Ogasawara 1, Oscar Luis Paredes 1, and Mitsuhiro Yokoyama 1

1 Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University, Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-ku, Kobe 650-0017, Japan

* To whom correspondence should be addressed.
Junya Shite, E-mail: shite{at}med.kobe-u.ac.jp


  Abstract

Aims Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity. Although plasma BNP decreases to a certain level by optimal treatment, there is significant heterogeneity in the baseline value among individuals. The underlying mechanism of the steady-state plasma BNP levels remains still controversial. We investigated the hypothesis that myocardial stiffness (Km) is a major determinant of the plasma BNP level.

Methods and results In 19 patients with diastolic HF [DHF; left ventricular ejection fraction (LVEF)≥45%], 18 with systolic HF (SHF; LVEF < 45%), and 12 controls, left ventricular (LV) performance variables and the results of the stress-strain analyses were obtained by the combined simultaneous measurement of echocardiographic and haemodynamic data, and compared with the plasma BNP level. In DHF, a significant correlation was observed between plasma BNP and fractional shortening (P = 0.010), pulmonary capillary wedge pressure (P = 0.030), end-diastolic pressure (P = 0.006), time constant of the LV isovolumic-pressure decline (P = 0.049), end-diastolic stress (P = 0.012), and Km (P = 0.004), respectively. In SHF, a significant correlation was observed between plasma BNP and end-diastolic stress (P = 0.036), chamber stiffness (P = 0.048), and Km (P = 0.003), respectively.

Conclusion In stable conditions, Km may be the most important determinant of the plasma BNP production in patients with both DHF and SHF.

Keywords: Heart failure; Brain natriuretic peptide; Myocardial stiffness.
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