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European Heart Journal Advance Access published online on March 16, 2006

European Heart Journal, doi:10.1093/eurheartj/ehi793
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received January 16, 2006
Accepted January 26, 2006

ESC Report

The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart

Jozef Bartunek 1, Stephanie Dimmeler 2, Helmut Drexler 3, Francisco Fernandez-Aviles 4, Manuel Galinanes 5, Stefan Janssens 6, John Martin 7 *, Anthony Mathur 8, Phillipe Menasche 9, Sylvia Priori 10, Bodo Strauer 11, Michal Tendera 12, William Wijns 13, and Andreas Zeiher 2

1 Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium
2 Molecular Cardiology, Department of Medicine III, J.W. Goethe University, Frankfurt, Germany
3 Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
4 Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico-Universitario, Valladolid, Spain
5 Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
6 Department of Cardiology, University Hospital, Gasthuisberg, Leuven, Belgium
7 Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, 5 University Street, London WC1E 6JJ
8 Department of Cardiology, London Chest Hospital, Bonner Road, London, UK
9 Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Cardiovascular Surgery, Universite Paris-Descartes, Faculte de Medecine, INSERM U 633, France
10 Department of Cardiology, University of Pavia, Italy
11 Heinrich-Heine-Universitat Dusseldorf, Klinik fur Kardiologie, Pneumologie und Angiologie, Moorenstr. 5 40225 Dusseldorf, Germany
12 3rd Division of Cardiology, School of Medicine, Katowice, Poland
13 Cardiovascular Centre Aalst, OLV Clinic, Aalst, Belgium

* To whom correspondence should be addressed.
John Martin, E-mail: john.martin{at}ucl.ac.uk


   Abstract

A task force has been established by the European Society of Cardiology to investigate the role of progenitor/stem cell therapy in the treatment of cardiovascular disease. This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart.

Keywords: Adult progenitor cell; Stem cell; Cardiovascular; Autologous; Growth factors; Cardiac repair; Bone marrow progenitor cell; Skeletal myoblast.
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