European Heart Journal Advance Access published online on March 14, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi830
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Cardiology, Hospital del Mar (IMAS-UAB), Passeig Marítim 25-29, E-08003 Barcelona, Spain
* To whom correspondence should be addressed. Aims To assess the level of pre-operative haemoglobin (HB) as a risk marker for morbidity and mortality in the early post-operative period of patients who underwent elective valve replacement. Methods and results Between January 1998 and March 2004, clinical and outcomes data were collected for the 201 patients who had elective valve replacement. For each gender, the criterion to choose the best cut-off point was that which achieved the maximum likelihood after several General Additive Model models performed in a Bootstrap procedure. The best cut-off point obtained for pre-operative HB was 12 g/dL. Overall peri-operative mortality (deaths occurring during hospital period or within 30 days) was 9.5%. After adjusting well-known independent pre-operative risk factors for operative mortality, pre-operative HB <12 g/dL was identified as an independent predictor for in-hospital mortality (OR, 3.23; 95% CI, 1.09-9.55; P = 0.03). Also adjusting for EuroScore, pre-operative HB remained significant (OR, 3.64; 95% CI, 1.32-10.06; P = 0.01). The same model was applied to post-operative morbidity, and pre-operative HB <12 g/dL was identified as an independent predictor with and without EuroScore (OR, 4.67; 95% CI, 2.03-10.71; P < 0.001), (OR, 5.18; 95% CI, 2.18-12.3; P < 0.001), respectively. Conclusion In patients undergoing elective valve replacement pre-operative HB <12 g/dL is a risk marker of in-hospital mortality and serious adverse outcomes.
Received April 19, 2005
Revised January 18, 2006
Accepted February 23, 2006
Clinical research
Is pre-operative anaemia a risk marker for in-hospital mortality and morbidity after valve replacement?
Mercè Cladellas 1 *,
Jordi Bruguera 1,
Josep Comín 1,
Joan Vila 2,
Elisabeth de Jaime 3,
Julio Martí 1,
and
Miquel Gomez 1
2 Institut Municipal d'Investigació Mèdica (IMIM)
3 Department of Geriatrics, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain
Mercè Cladellas, E-mail: mcladellas{at}imas.imim.es
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. De Santo, G. Romano, A. Della Corte, V. de Simone, F. Grimaldi, M. Cotrufo, and M. de Feo Preoperative anemia in patients undergoing coronary artery bypass grafting predicts acute kidney injury J. Thorac. Cardiovasc. Surg., October 1, 2009; 138(4): 965 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H.M. van Straten, M. A. Soliman Hamad, A. J. van Zundert, E. J. Martens, J. P.A.M. Schonberger, and A. M. de Wolf Preoperative Hemoglobin Level as a Predictor of Survival After Coronary Artery Bypass Grafting: A Comparison With the Matched General Population Circulation, July 14, 2009; 120(2): 118 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Karkouti, D. N. Wijeysundera, W. S. Beattie, and for the Reducing Bleeding in Cardiac Surgery (RBC) Risk Associated With Preoperative Anemia in Cardiac Surgery: A Multicenter Cohort Study Circulation, January 29, 2008; 117(4): 478 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ibanez, M. Riera, J. I. Saez de Ibarra, A. Carrillo, R. Fernandez, J. Herrero, M. Fiol, and O. Bonnin Effect of preoperative mild renal dysfunction on mortality and morbidity following valve cardiac surgery Interactive CardioVascular and Thoracic Surgery, December 1, 2007; 6(6): 748 - 752. [Abstract] [Full Text] [PDF]
|
|