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European Heart Journal Advance Access published online on March 16, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi831
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received August 21, 2005
Revised January 11, 2006
Accepted February 23, 2006

Clinical research

Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance

Aziz U. Momin 1, Narbeh Melikian 1, Ajay M. Shah 1, David J. Grieve 1, Stephen B. Wheatcroft 1, Lindsay John 2, Ahmed El Gamel 2, Jatin B. Desai 2, Toby Nelson 1, Catherine Driver 3, Roy A. Sherwood 3, and Mark T. Kearney 1 *

1 Cardiovascular Division, King's College School of Medicine at Guy's, King's College, and St Thomas' Hospitals, King's College London, Bessemer Road, London SE5 9PJ, UK
2 Department of Cardiothoracic Surgery, King's College Hospital, London, UK
3 Department of Clinical Biochemistry, King's College Hospital, London, UK

* To whom correspondence should be addressed.
Mark T. Kearney, E-mail: mark.kearney{at}kcl.ac.uk


  Abstract

Aims We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease.

Methods and results In 131 patients (age 65.7 ± 0.7 years mean ± SEM), ex vivo vascular reactivity to leptin (10 - 13-10 - 7 M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxation (maximal relaxation 24.5 ± 1.6%). In separate experiments, relaxation to leptin was unaffected by L-NMMA (17.4 ± 3.4 vs.17.8 ± 3.3%, P = 0.9) or endothelial denudation (17.4 ± 4.4 vs. 22.5 ± 3.0%, P = 0.4). We explored the possibility that leptin's vascular effects are mediated via smooth muscle hyperpolarization. In the presence of KCl (30 mmol/L) to inhibit hyperpolarization, the vasodilator effect of leptin was completely blocked (0.08 ± 4.1%, P < 0.001 vs. control). Similar results were demonstrated in internal mammary artery rings. The only independent correlate of leptin-mediated vasodilatation was plasma TNF-alpha (r = 0.25, P < 0.05). Neither body mass index nor waist circumference correlated with leptin-mediated vasorelaxation. This lack of a correlation with markers of total body fat/fat distribution suggests that leptin resistance may not extend to the vasculature.

Conclusion Leptin is a vasoactive peptide in human SV and internal mammary artery. Its action is not nitric oxide or endothelial-dependent. Markers of body fat did not correlate with leptin-mediated vasodilatation, raising the intriguing possibility of selective resistance to leptin's actions.

Keywords: Leptin; Nitric oxide; Endothelial function; Coronary artery disease.
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