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European Heart Journal Advance Access published online on April 19, 2006
European Heart Journal, doi:10.1093/eurheartj/ehi859
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European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received November 23, 2004
Revised March 10, 2006
Accepted March 17, 2006

Clinical research

Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: results of the prospective outcomes study in heart failure (POSH)

Martin R. Cowie 1 *, Michel Komajda 2, Tarita Murray-Thomas 1, Jonathan Underwood 1, Barry Ticho 3, and on behalf of the POSH Investigators

1 National Heart and Lung Institute, Imperial College, London, UK
2 Department of Cardiology, Hôpital Pitié-Salpétrière, Paris, France
3 Biogen Idec Cambridge, MA, USA

* To whom correspondence should be addressed.
Martin R. Cowie, E-mail: m.cowie{at}imperial.ac.uk


  Abstract

Aims To determine the prevalence and risk factors for worsening renal function (WRF) among patients hospitalized for decompensated heart failure (HF) and the association with subsequent re-hospitalization and mortality.

Methods and results We prospectively enrolled 299 patients across eight European countries (mean age 68, 74% men). HF was defined using the European Society of Cardiology criteria, but only patients with a history of ejection fraction ≤40% on echocardiography were recruited. WRF was defined as an increase in serum creatinine >26 µmol/L ({approx}0.3 mg/dL) from admission. Follow-up was 95% complete to 6 months. Nearly one-third of patients [72 of 248 patients, 29% (95% CI 26-32%)] developed WRF during hospitalization, excluding patients who had a major in-hospital complication likely to compromise renal function. The risk of WRF in this group was independently associated with serum creatinine levels on admission [odds ratio (OR) 3.02 (95% CI 1.58-5.76)], pulmonary oedema [OR 3.35 (1.79-6.27)], and a history of atrial fibrillation [OR 0.35 (0.18-0.67)]. Although the mortality of WRF patients was not increased significantly, the length of stay was 2 days longer [median 11 days (90% range (4-41) vs. 9 days (4-34), P=0.006]. The re-hospitalization rate was similar in both groups.

Conclusion WRF is common in patients admitted to European hospitals with decompensated HF. Such patients have longer duration admissions, but a similar mortality and re-hospitalization rate to those without WRF (if patients experiencing a major in-hospital complication are excluded).

Keywords: Heart failure; Worsening renal function; Risk factors; Prognosis; Hospitalization.
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