Skip Navigation



European Heart Journal Advance Access published online on June 19, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl109
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/14/1648    most recent
ehl109v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Goetze, J. P.
Right arrow Articles by Svendsen, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goetze, J. P.
Right arrow Articles by Svendsen, J. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received May 29, 2006
Accepted June 1, 2006

Current opinion

Atrial secretion of B-type natriuretic peptide

Jens Peter Goetze 1 *, Lennart Friis-Hansen 1, Jens F. Rehfeld 1, Brian Nilsson 2, and Jesper Hastrup Svendsen 2

1 Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark
2 Department of Cardiology, Rigshospitalet, University of Copenhagen, Denmark

* To whom correspondence should be addressed.
Jens Peter Goetze, E-mail: jpg{at}dadlnet.dk


  Abstract
In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how. Keywords: Atrial fibrillation; ANP; BNP; Heart failure; proANP; proBNP.

The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
A. J. Kerr, O. C. Raffel, G. A. Whalley, I. Zeng, and R. A. Stewart
Elevated B-type natriuretic peptide despite normal left ventricular function on rest and exercise stress echocardiography in mitral regurgitation
Eur. Heart J., February 1, 2008; 29(3): 363 - 370.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.