European Heart Journal Advance Access first published online on July 3, 2006
This version published online on July 7, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl133
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1 Department of Heart and Vessels, University of Florence, Viale Morgagni 85, Florence 50134, Italy
* To whom correspondence should be addressed. Aims The majority of tissue Doppler indexes proposed to predict left ventricular (LV) reverse remodelling in cardiac resynchronization therapy (CRT) reflects LV asynchrony as assessed in ejection phase. We evaluated the predictive value of a new strain-imaging parameter reflecting the total amount of time spent by 12 LV segments in contracting after aortic valve closure. Methods and results Fifty-nine patients who fulfilled current treatment recommendations were studied before and 6 months after CRT. Time to tissue Doppler systolic peak velocity (Ts) and time exceeding aortic closure (ExcT) in strain curves were measured in 12 LV segments. Ts standard deviation (Ts-SD) and sum of ExcT of overall 12 LV segments (oExcT) were analysed. After 6 months, responders were defined according to Conclusion o-ExcT is able to predict LV reverse remodelling after CRT.
Received January 31, 2006
Revised May 8, 2006
Accepted June 2, 2006
Clinical research
Utility of a new left ventricular asynchrony index as a predictor of reverse remodelling after cardiac resynchronization therapy
Maria Cristina Porciani 1 *,
Alessio Lilli 1,
Roberto Macioce 1,
Francesco Cappelli 1,
Gabriele Demarchi 1,
Alessia Pappone 1,
Giuseppe Ricciardi 1,
and
Luigi Padeletti 1
Maria Cristina Porciani, E-mail: cporciani{at}hotmail.com
Abstract 
15% LV end-systolic volume reduction. Responders (47%) when compared with non-responders (53%) had significantly higher baseline Ts-SD and oExcT values. Receiver operating characteristic (ROC) curve analysis demonstrated that an optimal cutoff value of 760 ms for oExcT yielded 93.5% sensitivity and 82.8% specificity. For Ts-SD at the cutoff of 32 ms, 82% sensitivity and 39% specificity were obtained. Area under ROC was significantly larger for oExcT than for Ts-SD.
The originally published version of this paper listed the authors' first names and surnames in the incorrect order. The publisher would like to apologize for this error.
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