Skip Navigation



European Heart Journal Advance Access published online on August 1, 2006
European Heart Journal, doi:10.1093/eurheartj/ehl160
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
27/18/2177    most recent
ehl160v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bonarjee, V. V.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonarjee, V. V.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

European Heart Journal © The European Society of Cardiology 2006; all rights reserved
Received August 29, 2005
Revised July 3, 2006
Accepted July 6, 2006

Clinical research

Sex-based short- and long-term survival in patients following complicated myocardial infarction

Vernon V.S. Bonarjee 1 *, Annika Rosengren 2, Steven M. Snapinn 3, Margaret K. James 3, and Kenneth Dickstein 1, on behalf of the OPTIMAAL study group

1 University of Bergen, Stavanger University Hospital, Stavanger, Norway
2 Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
3 Merck Research Laboratories, West Point, PA, USA

* To whom correspondence should be addressed.
Vernon V.S. Bonarjee, E-mail: bove{at}sir.no


  Abstract

Aims Mortality in women following an acute myocardial infarction (AMI) is higher than in men, in that women are older and have more co-morbidity at the time of AMI. We evaluated short- and long-term sex-related differences in management and prognosis among high-risk patients following AMI.

Methods and results A total of 1575 women and 3902 men with AMI and heart failure, left ventricular dysfunction, or anterior Q waves, were recruited for participation in the OPTIMAAL trial and followed for 2.7 ± 0.9 years in seven European countries. Symptomatic heart failure was more common in women when compared with men. Women were older, with more hypertension and diabetes mellitus. Fewer women were treated with thrombolytics (P < 0.001 in all cases). Women had a 1.37-fold higher risks of death (P < 0.001) during follow-up, but no differences were observed after adjusting for age. However, in-hospital mortality was significantly higher in women (4.89 vs. 2.54%; P < 0.001) and a 1.57-fold higher risk of in-hospital death (P = 0.006) persisted after adjusting for age and co-morbidities.

Conclusion Among high-risk patients with AMI, age-adjusted long-term survival was similar between sexes. However, adjusted in-hospital mortality was significantly higher in women. Higher short-term risk may warrant more rapid and appropriate management of women with AMI.

Keywords: Female gender; Myocardial infarction; Heart failure; Prognosis; Early mortality.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
L. J. Shaw, R. Bugiardini, and C. N. B. Merz
Women and ischemic heart disease: evolving knowledge.
J. Am. Coll. Cardiol., October 20, 2009; 54(17): 1561 - 1575.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
C. R. Jonassaint, S. H. Boyle, R. B. Williams, D. B. Mark, I. C. Siegler, and J. C. Barefoot
Facets of Openness Predict Mortality in Patients With Cardiac Disease
Psychosom Med, May 1, 2007; 69(4): 319 - 322.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.